DegronMD

Uniprot ID: Q9H5P4

Source protein: PDZ domain-containing protein 7

Source gene: PDZD7

Class: DEG_SCF_FBW7_1

Location: 799:806

E3 ligase: FBXW7

DEGRON score: 0.9233

ASA_SCORE: 83.725

COIL: 0.9335

CONS_SCORE: 0

DSS_SCORE: 0.8422

HELIX: 0.0223

FCONS_SCORE: 0

RIG_SCORE: 0.4996

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A804V	SIDM01245	T-Lymphoblastic Leukemia	GDSC	PVPTPAPS	DEG_SCF_FBW7_1	0.5825
p.A804V	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	PVPTPAPS	DEG_SCF_FBW7_1	0.5825
p.P815L	SIDM00217	Colorectal Carcinoma	GDSC	PVPTPAPS	DEG_SCF_FBW7_1	0.0833
p.P815L	SNU-1040	large_intestine	COSMIC	PVPTPAPS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H5P4	PDZ domain-containing protein 7	DEG_SCF_FBW7_1	799:806	PVPTPAPS	FBXW7	0.9233	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons