DegronMD - Q9H5Y7(SLITRK6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q578R	TCGA-69-7978	LUAD	TCGA	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.1944
p.Q578R	DO24920	LUAD	ICGC	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.1944
p.T596A	TCGA-95-7567	LUAD	TCGA	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.1667
p.T596A	DO25564	LUAD	ICGC	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.1667
p.T593M	TCGA-AP-A0LM	UCEC	TCGA	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.25
p.T593M	TCGA-AP-A1DV	UCEC	TCGA	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.25
p.T593M	DO43306	UCEC	ICGC	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.25
p.T593M	DO43186	UCEC	ICGC	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.25
p.L582I	TCGA-AX-A06F	UCEC	TCGA	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.3056
p.L582I	DO41752	UCEC	ICGC	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.3056
p.V584I	TCGA-BR-6453	STAD	TCGA	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation altering degron motif	0.5965
p.V584I	DO218874	SKCA	ICGC	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation altering degron motif	0.5965
p.V584I	DO38543	STAD	ICGC	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation altering degron motif	0.5965
p.M575V	TCGA-CN-6013	HNSC	TCGA	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.1111
p.M575V	DO15975	HNSC	ICGC	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.1111
p.S600F	TCGA-EE-A2MC	SKCM	TCGA	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.0556
p.S600F	DO37559	SKCM	ICGC	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.0556
p.A594T	TCGA-FI-A2D5	UCEC	TCGA	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.2222
p.A594T	DO41331	UCEC	ICGC	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.2222
p.R599Q	TCGA-FR-A69P	SKCM	TCGA	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.0833
p.R599Q	TCGA-FW-A3R5	SKCM	TCGA	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.0833
p.R599Q	DO47292	SKCM	ICGC	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.0833
p.R599Q	DO37406	SKCM	ICGC	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.0833
p.L582R	DO234158	ESAD	ICGC	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.3056
p.L582R	DO228551	GACA	ICGC	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.3056
p.S574Y	DO231730	LINC	ICGC	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.0833
p.I597V	DO232761	PBCA	ICGC	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.1389
p.L582F	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.3056
p.L582F	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	MVTTPATT	DEG_SCF_FBW7_1	583:590	Mutation rewiring degron network	0.3056

Kaplan plot for SLITRK6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLITRK6

UniProt ID: Q9H5Y7

Entrez ID: 84189

Protein name: SLIT and NTRK-like protein 6

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLITRK6 in