DegronMD

Uniprot ID: Q9H5Y7

Source protein: SLIT and NTRK-like protein 6

Source gene: SLITRK6

Class: DEG_SCF_FBW7_1

Location: 583:590

E3 ligase: FBXW7

DEGRON score: 0.9538

ASA_SCORE: 81.075

COIL: 0.7914

CONS_SCORE: 0.4528

DSS_SCORE: 0.3592

HELIX: 0.0334

FCONS_SCORE: 1.1209

RIG_SCORE: 0.7946

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q578R	TCGA-69-7978	LUAD	TCGA	MVTTPATT	DEG_SCF_FBW7_1	0.1944
p.Q578R	DO24920	LUAD	ICGC	MVTTPATT	DEG_SCF_FBW7_1	0.1944
p.T596A	TCGA-95-7567	LUAD	TCGA	MVTTPATT	DEG_SCF_FBW7_1	0.1667
p.T596A	DO25564	LUAD	ICGC	MVTTPATT	DEG_SCF_FBW7_1	0.1667
p.T593M	TCGA-AP-A0LM	UCEC	TCGA	MVTTPATT	DEG_SCF_FBW7_1	0.25
p.T593M	TCGA-AP-A1DV	UCEC	TCGA	MVTTPATT	DEG_SCF_FBW7_1	0.25
p.T593M	DO43306	UCEC	ICGC	MVTTPATT	DEG_SCF_FBW7_1	0.25
p.T593M	DO43186	UCEC	ICGC	MVTTPATT	DEG_SCF_FBW7_1	0.25
p.L582I	TCGA-AX-A06F	UCEC	TCGA	MVTTPATT	DEG_SCF_FBW7_1	0.3056
p.L582I	DO41752	UCEC	ICGC	MVTTPATT	DEG_SCF_FBW7_1	0.3056
p.V584I	TCGA-BR-6453	STAD	TCGA	MVTTPATT	DEG_SCF_FBW7_1	0.5965
p.V584I	DO218874	SKCA	ICGC	MVTTPATT	DEG_SCF_FBW7_1	0.5965
p.V584I	DO38543	STAD	ICGC	MVTTPATT	DEG_SCF_FBW7_1	0.5965
p.M575V	TCGA-CN-6013	HNSC	TCGA	MVTTPATT	DEG_SCF_FBW7_1	0.1111
p.M575V	DO15975	HNSC	ICGC	MVTTPATT	DEG_SCF_FBW7_1	0.1111
p.S600F	TCGA-EE-A2MC	SKCM	TCGA	MVTTPATT	DEG_SCF_FBW7_1	0.0556
p.S600F	DO37559	SKCM	ICGC	MVTTPATT	DEG_SCF_FBW7_1	0.0556
p.A594T	TCGA-FI-A2D5	UCEC	TCGA	MVTTPATT	DEG_SCF_FBW7_1	0.2222
p.A594T	DO41331	UCEC	ICGC	MVTTPATT	DEG_SCF_FBW7_1	0.2222
p.R599Q	TCGA-FR-A69P	SKCM	TCGA	MVTTPATT	DEG_SCF_FBW7_1	0.0833
p.R599Q	TCGA-FW-A3R5	SKCM	TCGA	MVTTPATT	DEG_SCF_FBW7_1	0.0833
p.R599Q	DO47292	SKCM	ICGC	MVTTPATT	DEG_SCF_FBW7_1	0.0833
p.R599Q	DO37406	SKCM	ICGC	MVTTPATT	DEG_SCF_FBW7_1	0.0833
p.L582R	DO234158	ESAD	ICGC	MVTTPATT	DEG_SCF_FBW7_1	0.3056
p.L582R	DO228551	GACA	ICGC	MVTTPATT	DEG_SCF_FBW7_1	0.3056
p.S574Y	DO231730	LINC	ICGC	MVTTPATT	DEG_SCF_FBW7_1	0.0833
p.I597V	DO232761	PBCA	ICGC	MVTTPATT	DEG_SCF_FBW7_1	0.1389
p.L582F	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	MVTTPATT	DEG_SCF_FBW7_1	0.3056
p.L582F	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	MVTTPATT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H5Y7	SLIT and NTRK-like protein 6	DEG_SCF_FBW7_1	583:590	MVTTPATT	FBXW7	0.9538	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MVTTPATT

Degron related mutations and impact score

Drug responses associated with SLITRK6 mutations

All proteins holding degron of MVTTPATT