DegronMD - Q9H6F5(CCDC86)

CCDC86

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R342W	TCGA-FI-A2D5	UCEC	TCGA	KRDTLALLQ	DEG_APCC_DBOX_1	341:349	Mutation altering degron motif	0.8634
p.R342W	DO41331	UCEC	ICGC	KRDTLALLQ	DEG_APCC_DBOX_1	341:349	Mutation altering degron motif	0.8634
p.R342W	SIDM00159	Biliary Tract Carcinoma	GDSC	KRDTLALLQ	DEG_APCC_DBOX_1	341:349	Mutation altering degron motif	0.8634
p.R342W	ACH-000182	Bile Duct Cancer	CCLE	KRDTLALLQ	DEG_APCC_DBOX_1	341:349	Mutation altering degron motif	0.8634
p.P356S	TCGA-HU-A4G9	STAD	TCGA	KRDTLALLQ	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.1389
p.P356S	DO47789	STAD	ICGC	KRDTLALLQ	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.1389
p.K332M	DO223041	ESCA	ICGC	KRDTLALLQ	DEG_APCC_DBOX_1	341:349	Mutation substituting flanking lysine	0.1944
p.K334Q	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	KRDTLALLQ	DEG_APCC_DBOX_1	341:349	Mutation substituting flanking lysine	0.25
p.K334Q	SIDM01413	Oral Cavity Carcinoma	GDSC	KRDTLALLQ	DEG_APCC_DBOX_1	341:349	Mutation substituting flanking lysine	0.25
p.P353L	SIDM00856	Other Solid Cancers	GDSC	KRDTLALLQ	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.2222
p.P353L	SIDM00931	Thyroid Gland Carcinoma	GDSC	KRDTLALLQ	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.2222
p.A358P	ACH-000088	Non-Cancerous	CCLE	KRDTLALLQ	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.0833
p.R342Q	ACH-000334	Lymphoma	CCLE	KRDTLALLQ	DEG_APCC_DBOX_1	341:349	Mutation altering degron motif	0.7329

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*NOTE: the Kaplan plots were collected from OncoLnc