DegronMD

Uniprot ID: Q9H6F5

Source protein: Coiled-coil domain-containing protein 86

Source gene: CCDC86

Class: DEG_APCC_DBOX_1

Location: 341:349

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9889

ASA_SCORE: 89.1111

COIL: 0.3613

CONS_SCORE: 0.5997

DSS_SCORE: 0.5822

HELIX: 0.6159

FCONS_SCORE: 1.09

RIG_SCORE: 0.7815

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R342W	TCGA-FI-A2D5	UCEC	TCGA	KRDTLALLQ	DEG_APCC_DBOX_1	0.8634
p.R342W	DO41331	UCEC	ICGC	KRDTLALLQ	DEG_APCC_DBOX_1	0.8634
p.R342W	SIDM00159	Biliary Tract Carcinoma	GDSC	KRDTLALLQ	DEG_APCC_DBOX_1	0.8634
p.R342W	ACH-000182	Bile Duct Cancer	CCLE	KRDTLALLQ	DEG_APCC_DBOX_1	0.8634
p.P356S	TCGA-HU-A4G9	STAD	TCGA	KRDTLALLQ	DEG_APCC_DBOX_1	0.1389
p.P356S	DO47789	STAD	ICGC	KRDTLALLQ	DEG_APCC_DBOX_1	0.1389
p.K332M	DO223041	ESCA	ICGC	KRDTLALLQ	DEG_APCC_DBOX_1	0.1944
p.K334Q	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	KRDTLALLQ	DEG_APCC_DBOX_1	0.25
p.K334Q	SIDM01413	Oral Cavity Carcinoma	GDSC	KRDTLALLQ	DEG_APCC_DBOX_1	0.25
p.P353L	SIDM00856	Other Solid Cancers	GDSC	KRDTLALLQ	DEG_APCC_DBOX_1	0.2222
p.P353L	SIDM00931	Thyroid Gland Carcinoma	GDSC	KRDTLALLQ	DEG_APCC_DBOX_1	0.2222
p.A358P	ACH-000088	Non-Cancerous	CCLE	KRDTLALLQ	DEG_APCC_DBOX_1	0.0833
p.R342Q	ACH-000334	Lymphoma	CCLE	KRDTLALLQ	DEG_APCC_DBOX_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H6F5	Coiled-coil domain-containing protein 86	DEG_APCC_DBOX_1	341:349	KRDTLALLQ	APC,CDC20,FZR1	0.9889	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons