DegronMD - Q9H6I2(SOX17)

GO - Biological processes (BP): anatomical structure morphogenesis [GO:0009653]; angiogenesis [GO:0001525]; cardiac cell fate determination [GO:0060913]; cardiogenic plate morphogenesis [GO:0003142]; cell differentiation [GO:0030154]; cell migration involved in gastrulation [GO:0042074]; cellular response to leukemia inhibitory factor [GO:1990830]; common bile duct development [GO:0061009]; embryonic foregut morphogenesis [GO:0048617]; embryonic heart tube development [GO:0035050]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cell differentiation [GO:0060956]; endocardium formation [GO:0060214]; endodermal cell fate determination [GO:0007493]; endodermal cell fate specification [GO:0001714]; endodermal digestive tract morphogenesis [GO:0061031]; endoderm formation [GO:0001706]; gall bladder development [GO:0061010]; heart development [GO:0007507]; heart formation [GO:0060914]; heart looping [GO:0001947]; inner cell mass cellular morphogenesis [GO:0001828]; metanephros development [GO:0001656]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of Wnt signaling pathway involved in heart development [GO:0003308]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell differentiation [GO:0045597]; positive regulation of gene expression [GO:0010628]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein destabilization [GO:0031648]; protein stabilization [GO:0050821]; regulation of cardiac cell fate specification [GO:2000043]; regulation of embryonic development [GO:0045995]; regulation of stem cell division [GO:2000035]; regulation of stem cell proliferation [GO:0072091]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; rostrocaudal neural tube patterning [GO:0021903]; signal transduction involved in regulation of gene expression [GO:0023019]; spermatogenesis [GO:0007283]; stem cell fate specification [GO:0048866]; ureter development [GO:0072189]; vasculogenesis [GO:0001570]; Wnt signaling pathway [GO:0016055] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A211V	TCGA-VQ-A91D	STAD	TCGA	PLPTPDTS	DEG_SCF_FBW7_1	218:225	Mutation rewiring degron network	0.1389
p.A211V	DO51783	STAD	ICGC	PLPTPDTS	DEG_SCF_FBW7_1	218:225	Mutation rewiring degron network	0.1389
p.T221M	DO52552	BRCA	ICGC	PLPTPDTS	DEG_SCF_FBW7_1	218:225	Mutation altering degron motif	0.7423
p.L219F	DO222785	COCA	ICGC	PLPTPDTS	DEG_SCF_FBW7_1	218:225	Mutation altering degron motif	0.587
p.D215N	DO224575	PACA	ICGC	PLPTPDTS	DEG_SCF_FBW7_1	218:225	Mutation rewiring degron network	0.25
p.D215N	ACH-000997	Colon/Colorectal Cancer	CCLE	PLPTPDTS	DEG_SCF_FBW7_1	218:225	Mutation rewiring degron network	0.25
p.L209M	DO232224	PBCA	ICGC	PLPTPDTS	DEG_SCF_FBW7_1	218:225	Mutation rewiring degron network	0.0833
p.T224M	ACH-000338	Lymphoma	CCLE	PLPTPDTS	DEG_SCF_FBW7_1	218:225	Mutation altering degron motif	0.6312

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SOX17

UniProt ID: Q9H6I2

Entrez ID: 64321

Protein name: Transcription factor SOX-17

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SOX17 in