DegronMD

Uniprot ID: Q9H6I2

Source protein: Transcription factor SOX-17

Source gene: SOX17

Class: DEG_SCF_FBW7_1

Location: 218:225

E3 ligase: FBXW7

DEGRON score: 0.9977

ASA_SCORE: 59.375

COIL: 0.9385

CONS_SCORE: 0.4689

DSS_SCORE: 0.6692

HELIX: 0.0234

FCONS_SCORE: 1.0683

RIG_SCORE: 0.6419

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A211V	TCGA-VQ-A91D	STAD	TCGA	PLPTPDTS	DEG_SCF_FBW7_1	0.1389
p.A211V	DO51783	STAD	ICGC	PLPTPDTS	DEG_SCF_FBW7_1	0.1389
p.T221M	DO52552	BRCA	ICGC	PLPTPDTS	DEG_SCF_FBW7_1	0.7423
p.L219F	DO222785	COCA	ICGC	PLPTPDTS	DEG_SCF_FBW7_1	0.587
p.D215N	DO224575	PACA	ICGC	PLPTPDTS	DEG_SCF_FBW7_1	0.25
p.D215N	ACH-000997	Colon/Colorectal Cancer	CCLE	PLPTPDTS	DEG_SCF_FBW7_1	0.25
p.L209M	DO232224	PBCA	ICGC	PLPTPDTS	DEG_SCF_FBW7_1	0.0833
p.T224M	ACH-000338	Lymphoma	CCLE	PLPTPDTS	DEG_SCF_FBW7_1	0.6312

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H6I2	Transcription factor SOX-17	DEG_SCF_FBW7_1	218:225	PLPTPDTS	FBXW7	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons