DegronMD - Q9H6K4(OPA3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R166Q	TCGA-EE-A3AE	SKCM	TCGA	LRTELQEVR	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.1667
p.R166Q	DO37802	SKCM	ICGC	LRTELQEVR	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.1667
p.S144P	DO233115	GACA	ICGC	LRTELQEVR	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.1111
p.Q157K	DO229037	LICA	ICGC	LRTELQEVR	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.5833
p.A143P	SIDM00602	Gastric Carcinoma	GDSC	LRTELQEVR	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.0833
p.A143P	ACH-000919	Gastric Cancer	CCLE	LRTELQEVR	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.0833
p.A143P	IM-95	stomach	COSMIC	LRTELQEVR	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.0833
p.C164Y	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LRTELQEVR	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.2222
p.C164Y	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LRTELQEVR	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.2222
p.E155K	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LRTELQEVR	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.591
p.E155K	ACH-002238	Leukemia	CCLE	LRTELQEVR	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.591
p.E155K	GR-ST	haematopoietic and lymphoid tissue	COSMIC	LRTELQEVR	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.591
p.R160C	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LRTELQEVR	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.719
p.A161S	SIDM00980	Gastric Carcinoma	GDSC	LRTELQEVR	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.3056
p.A161S	ACH-000948	Gastric Cancer	CCLE	LRTELQEVR	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.3056
p.A161S	23132-87	stomach	COSMIC	LRTELQEVR	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.3056
p.R160H	SIDM01608	Endometrial Carcinoma	GDSC	LRTELQEVR	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.7133
p.R160H	ACH-000990	Endometrial/Uterine Cancer	CCLE	LRTELQEVR	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.7133
p.P169S	ACH-001515	Cervical Cancer	CCLE	LRTELQEVR	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.0833

Kaplan plot for OPA3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OPA3

UniProt ID: Q9H6K4

Entrez ID: 80207

Protein name: Optic atrophy 3 protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OPA3 in