DegronMD

Uniprot ID: Q9H6K4

Source protein: Optic atrophy 3 protein

Source gene: OPA3

Class: DEG_APCC_DBOX_1

Location: 152:160

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.541

ASA_SCORE: 69.7111

COIL: 0.0394

CONS_SCORE: 0.3924

DSS_SCORE: 0.441

HELIX: 0.9596

FCONS_SCORE: 1.0715

RIG_SCORE: 0.8065

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R166Q	TCGA-EE-A3AE	SKCM	TCGA	LRTELQEVR	DEG_APCC_DBOX_1	0.1667
p.R166Q	DO37802	SKCM	ICGC	LRTELQEVR	DEG_APCC_DBOX_1	0.1667
p.S144P	DO233115	GACA	ICGC	LRTELQEVR	DEG_APCC_DBOX_1	0.1111
p.Q157K	DO229037	LICA	ICGC	LRTELQEVR	DEG_APCC_DBOX_1	0.5833
p.A143P	SIDM00602	Gastric Carcinoma	GDSC	LRTELQEVR	DEG_APCC_DBOX_1	0.0833
p.A143P	ACH-000919	Gastric Cancer	CCLE	LRTELQEVR	DEG_APCC_DBOX_1	0.0833
p.A143P	IM-95	stomach	COSMIC	LRTELQEVR	DEG_APCC_DBOX_1	0.0833
p.C164Y	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LRTELQEVR	DEG_APCC_DBOX_1	0.2222
p.C164Y	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LRTELQEVR	DEG_APCC_DBOX_1	0.2222
p.E155K	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LRTELQEVR	DEG_APCC_DBOX_1	0.591
p.E155K	ACH-002238	Leukemia	CCLE	LRTELQEVR	DEG_APCC_DBOX_1	0.591
p.E155K	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	LRTELQEVR	DEG_APCC_DBOX_1	0.591
p.R160C	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LRTELQEVR	DEG_APCC_DBOX_1	0.719
p.A161S	SIDM00980	Gastric Carcinoma	GDSC	LRTELQEVR	DEG_APCC_DBOX_1	0.3056
p.A161S	ACH-000948	Gastric Cancer	CCLE	LRTELQEVR	DEG_APCC_DBOX_1	0.3056
p.A161S	23132-87	stomach	COSMIC	LRTELQEVR	DEG_APCC_DBOX_1	0.3056
p.R160H	SIDM01608	Endometrial Carcinoma	GDSC	LRTELQEVR	DEG_APCC_DBOX_1	0.7133
p.R160H	ACH-000990	Endometrial/Uterine Cancer	CCLE	LRTELQEVR	DEG_APCC_DBOX_1	0.7133
p.P169S	ACH-001515	Cervical Cancer	CCLE	LRTELQEVR	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H6K4	Optic atrophy 3 protein	DEG_APCC_DBOX_1	152:160	LRTELQEVR	APC,CDC20,FZR1	0.541	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons