DegronMD - Q9H6P5(TASP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G230V	TCGA-98-A53J	LUSC	TCGA	DSGTLDT	DEG_SCF_TRCP1_1	228:234	Mutation altering degron motif	0.7532
p.G230V	DO219183	LUSC	ICGC	DSGTLDT	DEG_SCF_TRCP1_1	228:234	Mutation altering degron motif	0.7532
p.E243K	TCGA-AZ-4315	COAD	TCGA	DSGTLDT	DEG_SCF_TRCP1_1	228:234	Mutation rewiring degron network	0.0833
p.E243K	TCGA-F5-6814	READ	TCGA	DSGTLDT	DEG_SCF_TRCP1_1	228:234	Mutation rewiring degron network	0.0833
p.E243K	DO8842	COAD	ICGC	DSGTLDT	DEG_SCF_TRCP1_1	228:234	Mutation rewiring degron network	0.0833
p.E243K	DO36556	READ	ICGC	DSGTLDT	DEG_SCF_TRCP1_1	228:234	Mutation rewiring degron network	0.0833
p.E243K	SIDM01611	Endometrial Carcinoma	GDSC	DSGTLDT	DEG_SCF_TRCP1_1	228:234	Mutation rewiring degron network	0.0833
p.E243K	ACH-000961	Endometrial/Uterine Cancer	CCLE	DSGTLDT	DEG_SCF_TRCP1_1	228:234	Mutation rewiring degron network	0.0833
p.E243K	ACH-000996	Endometrial/Uterine Cancer	CCLE	DSGTLDT	DEG_SCF_TRCP1_1	228:234	Mutation rewiring degron network	0.0833
p.E243K	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGTLDT	DEG_SCF_TRCP1_1	228:234	Mutation rewiring degron network	0.0833
p.E226G	TCGA-HU-A4GQ	STAD	TCGA	DSGTLDT	DEG_SCF_TRCP1_1	228:234	Mutation rewiring degron network	0.2778
p.E226G	DO47767	STAD	ICGC	DSGTLDT	DEG_SCF_TRCP1_1	228:234	Mutation rewiring degron network	0.2778
p.R219I	DO222884	COCA	ICGC	DSGTLDT	DEG_SCF_TRCP1_1	228:234	Mutation rewiring degron network	0.0833
p.T234K	DO229027	LICA	ICGC	DSGTLDT	DEG_SCF_TRCP1_1	228:234	Mutation altering degron motif	0.7306
p.A237T	DO232761	PBCA	ICGC	DSGTLDT	DEG_SCF_TRCP1_1	228:234	Mutation rewiring degron network	0.25
p.R220K	SIDM00422	Hodgkin's Lymphoma	GDSC	DSGTLDT	DEG_SCF_TRCP1_1	228:234	Mutation rewiring degron network	0.1111
p.R220K	ACH-001203	Lymphoma	CCLE	DSGTLDT	DEG_SCF_TRCP1_1	228:234	Mutation rewiring degron network	0.1111
p.R220K	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	DSGTLDT	DEG_SCF_TRCP1_1	228:234	Mutation rewiring degron network	0.1111
p.H242R	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGTLDT	DEG_SCF_TRCP1_1	228:234	Mutation rewiring degron network	0.1111

Kaplan plot for TASP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TASP1

UniProt ID: Q9H6P5

Entrez ID: 55617

Protein name: Threonine aspartase 1 (Taspase-1) (EC 3.4.25.-) [Cleaved into: Threonine aspartase subunit alpha; Threonine aspartase subunit beta]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TASP1 in