DegronMD

Uniprot ID: Q9H6P5

Source protein: Threonine aspartase 1

Source gene: TASP1

Class: DEG_SCF_TRCP1_1

Location: 228:234

E3 ligase: BTRC

DEGRON score: 0.9116

ASA_SCORE: 54.2

COIL: 0.8894

CONS_SCORE: 0.4773

DSS_SCORE: 0.5257

HELIX: 0.0364

FCONS_SCORE: 1.0075

RIG_SCORE: 0.6898

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G230V	TCGA-98-A53J	LUSC	TCGA	DSGTLDT	DEG_SCF_TRCP1_1	0.7532
p.G230V	DO219183	LUSC	ICGC	DSGTLDT	DEG_SCF_TRCP1_1	0.7532
p.E243K	TCGA-AZ-4315	COAD	TCGA	DSGTLDT	DEG_SCF_TRCP1_1	0.0833
p.E243K	TCGA-F5-6814	READ	TCGA	DSGTLDT	DEG_SCF_TRCP1_1	0.0833
p.E243K	DO8842	COAD	ICGC	DSGTLDT	DEG_SCF_TRCP1_1	0.0833
p.E243K	DO36556	READ	ICGC	DSGTLDT	DEG_SCF_TRCP1_1	0.0833
p.E243K	SIDM01611	Endometrial Carcinoma	GDSC	DSGTLDT	DEG_SCF_TRCP1_1	0.0833
p.E243K	ACH-000961	Endometrial/Uterine Cancer	CCLE	DSGTLDT	DEG_SCF_TRCP1_1	0.0833
p.E243K	ACH-000996	Endometrial/Uterine Cancer	CCLE	DSGTLDT	DEG_SCF_TRCP1_1	0.0833
p.E243K	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGTLDT	DEG_SCF_TRCP1_1	0.0833
p.E226G	TCGA-HU-A4GQ	STAD	TCGA	DSGTLDT	DEG_SCF_TRCP1_1	0.2778
p.E226G	DO47767	STAD	ICGC	DSGTLDT	DEG_SCF_TRCP1_1	0.2778
p.R219I	DO222884	COCA	ICGC	DSGTLDT	DEG_SCF_TRCP1_1	0.0833
p.T234K	DO229027	LICA	ICGC	DSGTLDT	DEG_SCF_TRCP1_1	0.7306
p.A237T	DO232761	PBCA	ICGC	DSGTLDT	DEG_SCF_TRCP1_1	0.25
p.R220K	SIDM00422	Hodgkin's Lymphoma	GDSC	DSGTLDT	DEG_SCF_TRCP1_1	0.1111
p.R220K	ACH-001203	Lymphoma	CCLE	DSGTLDT	DEG_SCF_TRCP1_1	0.1111
p.R220K	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTLDT	DEG_SCF_TRCP1_1	0.1111
p.H242R	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGTLDT	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H6P5	Threonine aspartase 1	DEG_SCF_TRCP1_1	228:234	DSGTLDT	BTRC	0.9116	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons