DegronMD - Q9H7M6(ZSWIM4)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E433D	TCGA-AO-A03M	BRCA	TCGA	LTLYPD	LIG_APCC_ABBA_1	435:440	Mutation rewiring degron network	0.2778
p.E433D	DO2216	BRCA	ICGC	LTLYPD	LIG_APCC_ABBA_1	435:440	Mutation rewiring degron network	0.2778
p.T434K	TCGA-BR-8680	STAD	TCGA	LTLYPD	LIG_APCC_ABBA_1	435:440	Mutation rewiring degron network	0.3056
p.E431Q	TCGA-E7-A7XN	BLCA	TCGA	LTLYPD	LIG_APCC_ABBA_1	435:440	Mutation rewiring degron network	0.2222
p.R429H	TCGA-EO-A22U	UCEC	TCGA	LTLYPD	LIG_APCC_ABBA_1	435:440	Mutation rewiring degron network	0.1667
p.R429H	DO43755	UCEC	ICGC	LTLYPD	LIG_APCC_ABBA_1	435:440	Mutation rewiring degron network	0.1667
p.P439S	TCGA-FS-A1ZW	SKCM	TCGA	LTLYPD	LIG_APCC_ABBA_1	435:440	Mutation altering degron motif	0.5641
p.R429C	TCGA-YD-A89C	SKCM	TCGA	LTLYPD	LIG_APCC_ABBA_1	435:440	Mutation rewiring degron network	0.1667
p.R429C	DO219501	SKCM	ICGC	LTLYPD	LIG_APCC_ABBA_1	435:440	Mutation rewiring degron network	0.1667
p.R442C	DO50442	ESAD	ICGC	LTLYPD	LIG_APCC_ABBA_1	435:440	Mutation rewiring degron network	0.2778
p.M450T	DO46933	RECA	ICGC	LTLYPD	LIG_APCC_ABBA_1	435:440	Mutation rewiring degron network	0.0556
p.E444K	SIDM00683	Prostate Carcinoma	GDSC	LTLYPD	LIG_APCC_ABBA_1	435:440	Mutation rewiring degron network	0.2222
p.E444K	ACH-000977	lymph node	CCLE	LTLYPD	LIG_APCC_ABBA_1	435:440	Mutation rewiring degron network	0.2222
p.E444K	LNCaP-Clone-FGC	prostate	COSMIC	LTLYPD	LIG_APCC_ABBA_1	435:440	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons