DegronMD

Uniprot ID: Q9H7M6

Source protein: Zinc finger SWIM domain-containing protein 4

Source gene: ZSWIM4

Class: LIG_APCC_ABBA_1

Location: 435:440

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6937

ASA_SCORE: 70.85

COIL: 0.7627

CONS_SCORE: 0.4028

DSS_SCORE: 0.3677

HELIX: 0.1943

FCONS_SCORE: 0.7794

RIG_SCORE: 0.7789

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E433D	TCGA-AO-A03M	BRCA	TCGA	LTLYPD	LIG_APCC_ABBA_1	0.2778
p.E433D	DO2216	BRCA	ICGC	LTLYPD	LIG_APCC_ABBA_1	0.2778
p.T434K	TCGA-BR-8680	STAD	TCGA	LTLYPD	LIG_APCC_ABBA_1	0.3056
p.E431Q	TCGA-E7-A7XN	BLCA	TCGA	LTLYPD	LIG_APCC_ABBA_1	0.2222
p.R429H	TCGA-EO-A22U	UCEC	TCGA	LTLYPD	LIG_APCC_ABBA_1	0.1667
p.R429H	DO43755	UCEC	ICGC	LTLYPD	LIG_APCC_ABBA_1	0.1667
p.P439S	TCGA-FS-A1ZW	SKCM	TCGA	LTLYPD	LIG_APCC_ABBA_1	0.5641
p.R429C	TCGA-YD-A89C	SKCM	TCGA	LTLYPD	LIG_APCC_ABBA_1	0.1667
p.R429C	DO219501	SKCM	ICGC	LTLYPD	LIG_APCC_ABBA_1	0.1667
p.R442C	DO50442	ESAD	ICGC	LTLYPD	LIG_APCC_ABBA_1	0.2778
p.M450T	DO46933	RECA	ICGC	LTLYPD	LIG_APCC_ABBA_1	0.0556
p.E444K	SIDM00683	Prostate Carcinoma	GDSC	LTLYPD	LIG_APCC_ABBA_1	0.2222
p.E444K	ACH-000977	lymph_node	CCLE	LTLYPD	LIG_APCC_ABBA_1	0.2222
p.E444K	LNCaP-Clone-FGC	prostate	COSMIC	LTLYPD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7M6	Zinc finger SWIM domain-containing protein 4	LIG_APCC_ABBA_1	435:440	LTLYPD	APC,CDC20,FZR1	0.6937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons