VSIR
UniProt ID: Q9H7M9
Entrez ID: 64115
Protein name: V-type immunoglobulin domain-containing suppressor of T-cell activation (Platelet receptor Gi24) (Stress-induced secreted protein-1) (Sisp-1) (V-set domain-containing immunoregulatory receptor) (V-set immunoregulatory receptor)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777). {ECO:0000250|UniProtKB:Q9D659, ECO:0000269|PubM...
FUNCTION: Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777). {ECO:0000250|UniProtKB:Q9D659, ECO:0000269|PubMed:20666777, ECO:0000269|PubMed:24691993}.
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GO - Biological processes (BP):
negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000565]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of interleukin-10 production [GO:0032693]; negati...
negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000565]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of cell migration [GO:0030335]; positive regulation of collagen catabolic process [GO:0120158]; positive regulation of endopeptidase activity [GO:0010950]; positive regulation of gene expression [GO:0010628]; positive regulation of regulatory T cell differentiation [GO:0045591]; regulation of immune response [GO:0050776]; zymogen activation [GO:0031638]
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GO - Molecular function (MF):
endopeptidase activator activity [GO:0061133]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]...
endopeptidase activator activity [GO:0061133]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]
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GO - Cellular component (CC):
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]...
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]
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VSIR
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Kaplan plot for VSIR in
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*NOTE: the Kaplan plots were collected from OncoLnc