DegronMD

Uniprot ID: Q9H7M9

Source protein: V-type immunoglobulin domain-containing suppressor of T-cell activation

Source gene: VSIR

Class: DEG_APCC_DBOX_1

Location: 259:267

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7599

ASA_SCORE: 66.7778

COIL: 0.5286

CONS_SCORE: 0.5866

DSS_SCORE: 0.6277

HELIX: 0.396

FCONS_SCORE: 0.8803

RIG_SCORE: 0.7132

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R269Q	SIDM00499	Prostate Carcinoma	GDSC	VRHPLSYVA	DEG_APCC_DBOX_1	0.2778
p.G253R	SIDM00422	Hodgkin's Lymphoma	GDSC	VRHPLSYVA	DEG_APCC_DBOX_1	0.1667
p.G253R	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	VRHPLSYVA	DEG_APCC_DBOX_1	0.1667
p.R276W	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VRHPLSYVA	DEG_APCC_DBOX_1	0.0833
p.P249T	SIDM01463	Endometrial Carcinoma	GDSC	VRHPLSYVA	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7M9	V-type immunoglobulin domain-containing suppressor of T-cell activation	DEG_APCC_DBOX_1	259:267	VRHPLSYVA	APC,CDC20,FZR1	0.7599	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons