DegronMD - Q9H875(PRKRIP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A166S	TCGA-44-7667	LUAD	TCGA	TEEEEEVPSF	DEG_COP1_1	171:180	Mutation rewiring degron network	0.1944
p.A166S	DO23830	LUAD	ICGC	TEEEEEVPSF	DEG_COP1_1	171:180	Mutation rewiring degron network	0.1944
p.S165Y	TCGA-ER-A19P	SKCM	TCGA	TEEEEEVPSF	DEG_COP1_1	171:180	Mutation rewiring degron network	0.1667
p.S165Y	DO47623	SKCM	ICGC	TEEEEEVPSF	DEG_COP1_1	171:180	Mutation rewiring degron network	0.1667
p.E173K	TCGA-JW-A5VL	CESC	TCGA	TEEEEEVPSF	DEG_COP1_1	171:180	Mutation altering degron motif	0.591
p.E173K	DO49976	CESC	ICGC	TEEEEEVPSF	DEG_COP1_1	171:180	Mutation altering degron motif	0.591
p.S163T	TCGA-L5-A8NK	ESCA	TCGA	TEEEEEVPSF	DEG_COP1_1	171:180	Mutation blocking phosphorylation signal	0.5556
p.S164R	TCGA-L5-A8NK	ESCA	TCGA	TEEEEEVPSF	DEG_COP1_1	171:180	Mutation rewiring degron network	0.1389
p.E173Q	DO234455	ESAD	ICGC	TEEEEEVPSF	DEG_COP1_1	171:180	Mutation altering degron motif	0.5633
p.A166V	DO234414	ESAD	ICGC	TEEEEEVPSF	DEG_COP1_1	171:180	Mutation rewiring degron network	0.1944
p.A166V	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	TEEEEEVPSF	DEG_COP1_1	171:180	Mutation rewiring degron network	0.1944
p.A166V	EMC-BAC-2	lung	COSMIC	TEEEEEVPSF	DEG_COP1_1	171:180	Mutation rewiring degron network	0.1944
p.R184Q	DO33336	PACA	ICGC	TEEEEEVPSF	DEG_COP1_1	171:180	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons