DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
TEEEEEVPSF
Uniprot ID:
Q9H875
Source protein:
PRKR-interacting protein 1
Source gene:
PRKRIP1
Class:
DEG_COP1_1
Location:
171:180
E3 ligase:
COP1
DEGRON score:
0.5719
ASA_SCORE:
97.2
COIL:
0.6866
CONS_SCORE:
0.5846
DSS_SCORE:
0.8542
HELIX:
0.1931
FCONS_SCORE:
1.009
RIG_SCORE:
0.6566
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A166S
TCGA-44-7667
LUAD
TCGA
TEEEEEVPSF
DEG_COP1_1
0.1944
p.A166S
DO23830
LUAD
ICGC
TEEEEEVPSF
DEG_COP1_1
0.1944
p.S165Y
TCGA-ER-A19P
SKCM
TCGA
TEEEEEVPSF
DEG_COP1_1
0.1667
p.S165Y
DO47623
SKCM
ICGC
TEEEEEVPSF
DEG_COP1_1
0.1667
p.E173K
TCGA-JW-A5VL
CESC
TCGA
TEEEEEVPSF
DEG_COP1_1
0.591
p.E173K
DO49976
CESC
ICGC
TEEEEEVPSF
DEG_COP1_1
0.591
p.S163T
TCGA-L5-A8NK
ESCA
TCGA
TEEEEEVPSF
DEG_COP1_1
0.5556
p.S164R
TCGA-L5-A8NK
ESCA
TCGA
TEEEEEVPSF
DEG_COP1_1
0.1389
p.E173Q
DO234455
ESAD
ICGC
TEEEEEVPSF
DEG_COP1_1
0.5633
p.A166V
DO234414
ESAD
ICGC
TEEEEEVPSF
DEG_COP1_1
0.1944
p.A166V
SIDM00047
Non-Small Cell Lung Carcinoma
GDSC
TEEEEEVPSF
DEG_COP1_1
0.1944
p.A166V
EMC-BAC-2
lung
COSMIC
TEEEEEVPSF
DEG_COP1_1
0.1944
p.R184Q
DO33336
PACA
ICGC
TEEEEEVPSF
DEG_COP1_1
0.2222
Drug responses associated with PRKRIP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of TEEEEEVPSF
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H875
PRKR-interacting protein 1
DEG_COP1_1
171:180
TEEEEEVPSF
COP1
0.5719
More...