DegronMD - Q9H8M5(CNNM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E836K	TCGA-AP-A1DK	UCEC	TCGA	MDKTPQSS	DEG_SCF_FBW7_1	821:828	Mutation rewiring degron network	0.1111
p.L837F	TCGA-YC-A89H	BLCA	TCGA	MDKTPQSS	DEG_SCF_FBW7_1	821:828	Mutation rewiring degron network	0.0833
p.L837F	SIDM00893	Breast Carcinoma	GDSC	MDKTPQSS	DEG_SCF_FBW7_1	821:828	Mutation rewiring degron network	0.0833
p.L837F	ACH-000536	Breast Cancer	CCLE	MDKTPQSS	DEG_SCF_FBW7_1	821:828	Mutation rewiring degron network	0.0833
p.L837F	BT-20	breast	COSMIC	MDKTPQSS	DEG_SCF_FBW7_1	821:828	Mutation rewiring degron network	0.0833
p.L815F	DO51948	BLCA	ICGC	MDKTPQSS	DEG_SCF_FBW7_1	821:828	Mutation rewiring degron network	0.1667
p.L815F	BT-20	breast	COSMIC	MDKTPQSS	DEG_SCF_FBW7_1	821:828	Mutation rewiring degron network	0.1667
p.E827K	DO222775	MELA	ICGC	MDKTPQSS	DEG_SCF_FBW7_1	821:828	Mutation altering degron motif	0.7022
p.E827K	DO47665	SKCM	ICGC	MDKTPQSS	DEG_SCF_FBW7_1	821:828	Mutation altering degron motif	0.7022
p.V838L	DO51407	PRAD	ICGC	MDKTPQSS	DEG_SCF_FBW7_1	821:828	Mutation rewiring degron network	0.0556
p.E814K	DO42033	UCEC	ICGC	MDKTPQSS	DEG_SCF_FBW7_1	821:828	Mutation rewiring degron network	0.1389
p.A815S	SIDM01609	Endometrial Carcinoma	GDSC	MDKTPQSS	DEG_SCF_FBW7_1	821:828	Mutation rewiring degron network	0.1667
p.A815S	ACH-000972	Endometrial/Uterine Cancer	CCLE	MDKTPQSS	DEG_SCF_FBW7_1	821:828	Mutation rewiring degron network	0.1667
p.A829D	NB17	autonomic ganglia	COSMIC	MDKTPQSS	DEG_SCF_FBW7_1	821:828	Mutation rewiring degron network	0.3056
p.T828I	HCT-15	large intestine	COSMIC	MDKTPQSS	DEG_SCF_FBW7_1	821:828	Mutation altering degron motif	0.7078

Kaplan plot for CNNM2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CNNM2

UniProt ID: Q9H8M5

Entrez ID: 54805

Protein name: Metal transporter CNNM2 (Ancient conserved domain-containing protein 2) (Cyclin-M2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CNNM2 in