DegronMD

Uniprot ID: Q9H8M5

Source protein: Metal transporter CNNM2

Source gene: CNNM2

Class: DEG_SCF_FBW7_1

Location: 821:828

E3 ligase: FBXW7

DEGRON score: 0.6119

ASA_SCORE: 90.675

COIL: 0.8749

CONS_SCORE: 0.2575

DSS_SCORE: 0.6116

HELIX: 0.1029

FCONS_SCORE: 1.0597

RIG_SCORE: 0.6385

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E836K	TCGA-AP-A1DK	UCEC	TCGA	MDKTPQSS	DEG_SCF_FBW7_1	0.1111
p.L837F	TCGA-YC-A89H	BLCA	TCGA	MDKTPQSS	DEG_SCF_FBW7_1	0.0833
p.L837F	SIDM00893	Breast Carcinoma	GDSC	MDKTPQSS	DEG_SCF_FBW7_1	0.0833
p.L837F	ACH-000536	Breast Cancer	CCLE	MDKTPQSS	DEG_SCF_FBW7_1	0.0833
p.L837F	BT-20	breast	COSMIC	MDKTPQSS	DEG_SCF_FBW7_1	0.0833
p.L815F	DO51948	BLCA	ICGC	MDKTPQSS	DEG_SCF_FBW7_1	0.1667
p.L815F	BT-20	breast	COSMIC	MDKTPQSS	DEG_SCF_FBW7_1	0.1667
p.E827K	DO222775	MELA	ICGC	MDKTPQSS	DEG_SCF_FBW7_1	0.7022
p.E827K	DO47665	SKCM	ICGC	MDKTPQSS	DEG_SCF_FBW7_1	0.7022
p.V838L	DO51407	PRAD	ICGC	MDKTPQSS	DEG_SCF_FBW7_1	0.0556
p.E814K	DO42033	UCEC	ICGC	MDKTPQSS	DEG_SCF_FBW7_1	0.1389
p.A815S	SIDM01609	Endometrial Carcinoma	GDSC	MDKTPQSS	DEG_SCF_FBW7_1	0.1667
p.A815S	ACH-000972	Endometrial/Uterine Cancer	CCLE	MDKTPQSS	DEG_SCF_FBW7_1	0.1667
p.A829D	NB17	autonomic_ganglia	COSMIC	MDKTPQSS	DEG_SCF_FBW7_1	0.3056
p.T828I	HCT-15	large_intestine	COSMIC	MDKTPQSS	DEG_SCF_FBW7_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H8M5	Metal transporter CNNM2	DEG_SCF_FBW7_1	821:828	MDKTPQSS	FBXW7	0.6119	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons