DegronMD - Q9H900(ZWILCH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G104A	TCGA-44-7667	LUAD	TCGA	DFSTGE	DEG_Kelch_Keap1_1	89:94	Mutation rewiring degron network	0.0556
p.G104A	DO23830	LUAD	ICGC	DFSTGE	DEG_Kelch_Keap1_1	89:94	Mutation rewiring degron network	0.0556
p.S91Y	TCGA-A4-7583	KIRP	TCGA	DFSTGE	DEG_Kelch_Keap1_1	89:94	Mutation altering degron motif	0.8231
p.S91Y	DO20870	KIRP	ICGC	DFSTGE	DEG_Kelch_Keap1_1	89:94	Mutation altering degron motif	0.8231
p.S91Y	DO229253	THCA	ICGC	DFSTGE	DEG_Kelch_Keap1_1	89:94	Mutation altering degron motif	0.8231
p.S82C	TCGA-B6-A0IK	BRCA	TCGA	DFSTGE	DEG_Kelch_Keap1_1	89:94	Mutation blocking phosphorylation signal	0.5833
p.S82C	DO1902	BRCA	ICGC	DFSTGE	DEG_Kelch_Keap1_1	89:94	Mutation blocking phosphorylation signal	0.5833
p.E93A	DO233898	GACA	ICGC	DFSTGE	DEG_Kelch_Keap1_1	89:94	Mutation altering degron motif	0.7701
p.V103F	DO228971	LICA	ICGC	DFSTGE	DEG_Kelch_Keap1_1	89:94	Mutation rewiring degron network	0.0833
p.P102T	DO229275	THCA	ICGC	DFSTGE	DEG_Kelch_Keap1_1	89:94	Mutation rewiring degron network	0.1111
p.S88C	SIDM01174	Cervical Carcinoma	GDSC	DFSTGE	DEG_Kelch_Keap1_1	89:94	Mutation blocking phosphorylation signal	0.75
p.S88C	ACH-001402	Cervical Cancer	CCLE	DFSTGE	DEG_Kelch_Keap1_1	89:94	Mutation blocking phosphorylation signal	0.75
p.S88C	SW756	cervix	COSMIC	DFSTGE	DEG_Kelch_Keap1_1	89:94	Mutation blocking phosphorylation signal	0.75
p.E94K	SIDM01322	Oral Cavity Carcinoma	GDSC	DFSTGE	DEG_Kelch_Keap1_1	89:94	Mutation altering degron motif	0.7022
p.S98C	UM-UC-3	urinary tract	COSMIC	DFSTGE	DEG_Kelch_Keap1_1	89:94	Mutation rewiring degron network	0.2222
p.Y92C	SNU-C5	large intestine	COSMIC	DFSTGE	DEG_Kelch_Keap1_1	89:94	Mutation altering degron motif	0.7087

Kaplan plot for ZWILCH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZWILCH

UniProt ID: Q9H900

Entrez ID: 55055

Protein name: Protein zwilch homolog (hZwilch)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZWILCH in