DegronMD

Uniprot ID: Q9H900

Source protein: Protein zwilch homolog

Source gene: ZWILCH

Class: DEG_Kelch_Keap1_1

Location: 89:94

E3 ligase: KEAP1

DEGRON score: 0.9979

ASA_SCORE: 81.9333

COIL: 0.7898

CONS_SCORE: 0.4379

DSS_SCORE: 0.4419

HELIX: 0.1578

FCONS_SCORE: 1.024

RIG_SCORE: 0.7059

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G104A	TCGA-44-7667	LUAD	TCGA	DFSTGE	DEG_Kelch_Keap1_1	0.0556
p.G104A	DO23830	LUAD	ICGC	DFSTGE	DEG_Kelch_Keap1_1	0.0556
p.S91Y	TCGA-A4-7583	KIRP	TCGA	DFSTGE	DEG_Kelch_Keap1_1	0.8231
p.S91Y	DO20870	KIRP	ICGC	DFSTGE	DEG_Kelch_Keap1_1	0.8231
p.S91Y	DO229253	THCA	ICGC	DFSTGE	DEG_Kelch_Keap1_1	0.8231
p.S82C	TCGA-B6-A0IK	BRCA	TCGA	DFSTGE	DEG_Kelch_Keap1_1	0.5833
p.S82C	DO1902	BRCA	ICGC	DFSTGE	DEG_Kelch_Keap1_1	0.5833
p.E93A	DO233898	GACA	ICGC	DFSTGE	DEG_Kelch_Keap1_1	0.7701
p.V103F	DO228971	LICA	ICGC	DFSTGE	DEG_Kelch_Keap1_1	0.0833
p.P102T	DO229275	THCA	ICGC	DFSTGE	DEG_Kelch_Keap1_1	0.1111
p.S88C	SIDM01174	Cervical Carcinoma	GDSC	DFSTGE	DEG_Kelch_Keap1_1	0.75
p.S88C	ACH-001402	Cervical Cancer	CCLE	DFSTGE	DEG_Kelch_Keap1_1	0.75
p.S88C	SW756	cervix	COSMIC	DFSTGE	DEG_Kelch_Keap1_1	0.75
p.E94K	SIDM01322	Oral Cavity Carcinoma	GDSC	DFSTGE	DEG_Kelch_Keap1_1	0.7022
p.S98C	UM-UC-3	urinary_tract	COSMIC	DFSTGE	DEG_Kelch_Keap1_1	0.2222
p.Y92C	SNU-C5	large_intestine	COSMIC	DFSTGE	DEG_Kelch_Keap1_1	0.7087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H900	Protein zwilch homolog	DEG_Kelch_Keap1_1	89:94	DFSTGE	KEAP1	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons