VIPAS39
UniProt ID: Q9H9C1
Entrez ID: 63894
Protein name: Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysos...
FUNCTION: Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B (PubMed:19109425). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity). {ECO:0000250|UniProtKB:Q23288, ECO:0000269|PubMed:19109425, ECO:0000269|PubMed:20190753}.
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GO - Biological processes (BP):
cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; peptidyl-lysine hydroxylation [GO:0017185]; phagosom...
cell differentiation [GO:0030154]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; peptidyl-lysine hydroxylation [GO:0017185]; phagosome-lysosome fusion [GO:0090385]; post-translational protein modification [GO:0043687]; spermatogenesis [GO:0007283]; vacuolar transport [GO:0007034]
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GO - Molecular function (MF):
protein-containing complex binding [GO:0044877]...
protein-containing complex binding [GO:0044877]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; recycling endosome [GO:0055037]; vesicle tethering complex [GO:0099023]...
cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; recycling endosome [GO:0055037]; vesicle tethering complex [GO:0099023]
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VIPAS39
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*NOTE: the Kaplan plots were collected from OncoLnc