DegronMD

Uniprot ID: Q9H9C1

Source protein: Spermatogenesis-defective protein 39 homolog

Source gene: VIPAS39

Class: DEG_SCF_FBW7_1

Location: 129:136

E3 ligase: FBXW7

DEGRON score: 0.8903

ASA_SCORE: 77.0875

COIL: 0.7256

CONS_SCORE: 0.3969

DSS_SCORE: 0.5174

HELIX: 0.2358

FCONS_SCORE: 0.944

RIG_SCORE: 0.6861

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F122V	TCGA-AX-A06F	UCEC	TCGA	LSDTPAKS	DEG_SCF_FBW7_1	0.1389
p.A138V	TCGA-EE-A3AA	SKCM	TCGA	LSDTPAKS	DEG_SCF_FBW7_1	0.2778
p.G120E	TCGA-FD-A3SS	BLCA	TCGA	LSDTPAKS	DEG_SCF_FBW7_1	0.0833
p.G146E	DO737	BLCA	ICGC	LSDTPAKS	DEG_SCF_FBW7_1	0.0556
p.F120L	DO10068	COAD	ICGC	LSDTPAKS	DEG_SCF_FBW7_1	0.0833
p.G141D	DO18036	KIRC	ICGC	LSDTPAKS	DEG_SCF_FBW7_1	0.1944
p.S119G	DO41331	UCEC	ICGC	LSDTPAKS	DEG_SCF_FBW7_1	0.0556
p.R143K	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	LSDTPAKS	DEG_SCF_FBW7_1	0.1389
p.R143K	ACH-000789	Lung Cancer	CCLE	LSDTPAKS	DEG_SCF_FBW7_1	0.1389
p.R143K	NCI-H810	lung	COSMIC	LSDTPAKS	DEG_SCF_FBW7_1	0.1389
p.D131N	SIDM01664	Prostate Carcinoma	GDSC	LSDTPAKS	DEG_SCF_FBW7_1	0.5821
p.D131N	ACH-000952	Prostate Cancer	CCLE	LSDTPAKS	DEG_SCF_FBW7_1	0.5821
p.Y137C	SIDM01662	Plasma Cell Myeloma	GDSC	LSDTPAKS	DEG_SCF_FBW7_1	0.3056
p.Y137C	ACH-000564	Myeloma	CCLE	LSDTPAKS	DEG_SCF_FBW7_1	0.3056
p.Q123L	ACH-002669	Colon/Colorectal Cancer	CCLE	LSDTPAKS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H9C1	Spermatogenesis-defective protein 39 homolog	DEG_SCF_FBW7_1	129:136	LSDTPAKS	FBXW7	0.8903	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons