DegronMD - Q9H9P2(CHODL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q128K	TCGA-05-4396	LUAD	TCGA	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.25
p.Q128K	TCGA-EE-A3AA	SKCM	TCGA	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.25
p.R130L	TCGA-17-Z031	LUAD	TCGA	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.3056
p.R130L	TCGA-60-2720	LUSC	TCGA	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.3056
p.C144Y	TCGA-AJ-A3EK	UCEC	TCGA	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.1389
p.G140E	TCGA-AP-A1DV	UCEC	TCGA	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.25
p.G140E	TCGA-AX-A2HC	UCEC	TCGA	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.25
p.G140E	SIDM00890	Melanoma	GDSC	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.25
p.G140E	C32	skin	COSMIC	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.25
p.S127P	TCGA-EE-A2MF	SKCM	TCGA	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.2222
p.G124R	TCGA-EE-A2MR	SKCM	TCGA	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.1389
p.E136K	TCGA-FS-A1ZK	SKCM	TCGA	NWYTDEP	CBL_PTK	131:137	Mutation altering degron motif	0.591
p.G140R	TCGA-MB-A8JL	SARC	TCGA	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.25
p.G140R	ACH-000586	Lung Cancer	CCLE	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.25
p.G140R	NCI-H1876	lung	COSMIC	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.25
p.P145S	DO25010	LUAD	ICGC	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.1111
p.P145S	DO37966	SKCM	ICGC	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.1111
p.T146A	DO27295	LUSC	ICGC	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.0833
p.I143N	DO220912	MELA	ICGC	NWYTDEP	CBL_PTK	131:137	Mutation substituting flanking lysine	0.2778
p.K132N	DO232761	PBCA	ICGC	NWYTDEP	CBL_PTK	131:137	Mutation altering degron motif	0.6918
p.D126N	DO51282	SKCM	ICGC	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.1944
p.C137Y	DO223286	UCEC	ICGC	NWYTDEP	CBL_PTK	131:137	Mutation altering degron motif	0.7087
p.S141R	SIDM02040	Esophageal Carcinoma	GDSC	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.2222
p.S138F	SIDM00581	Glioblastoma	GDSC	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.3056
p.S138F	ACH-000738	Brain Cancer	CCLE	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.3056
p.S138F	GB-1	central nervous system	COSMIC	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.3056
p.W124R	23132-87	stomach	COSMIC	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.1389
p.I136F	SU-DHL-6	haematopoietic and lymphoid tissue	COSMIC	NWYTDEP	CBL_PTK	131:137	Mutation altering degron motif	0.7415
p.W146R	23132-87	stomach	COSMIC	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.0833
p.G121E	C32	skin	COSMIC	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.0556
p.G121R	NCI-H1876	lung	COSMIC	NWYTDEP	CBL_PTK	131:137	Mutation rewiring degron network	0.0556

Kaplan plot for CHODL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHODL

UniProt ID: Q9H9P2

Entrez ID: 140578

Protein name: Chondrolectin (Transmembrane protein MT75)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHODL in