DegronMD

Uniprot ID: Q9H9P2

Source protein: Chondrolectin

Source gene: CHODL

Class: CBL_PTK

Location: 131:137

E3 ligase: CBL

DEGRON score: 0.9728

ASA_SCORE: 64.6429

COIL: 0.8747

CONS_SCORE: 0.7505

DSS_SCORE: 0.3499

HELIX: 0.0173

FCONS_SCORE: 1.1033

RIG_SCORE: 0.7789

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q128K	TCGA-05-4396	LUAD	TCGA	NWYTDEP	CBL_PTK	0.25
p.Q128K	TCGA-EE-A3AA	SKCM	TCGA	NWYTDEP	CBL_PTK	0.25
p.R130L	TCGA-17-Z031	LUAD	TCGA	NWYTDEP	CBL_PTK	0.3056
p.R130L	TCGA-60-2720	LUSC	TCGA	NWYTDEP	CBL_PTK	0.3056
p.C144Y	TCGA-AJ-A3EK	UCEC	TCGA	NWYTDEP	CBL_PTK	0.1389
p.G140E	TCGA-AP-A1DV	UCEC	TCGA	NWYTDEP	CBL_PTK	0.25
p.G140E	TCGA-AX-A2HC	UCEC	TCGA	NWYTDEP	CBL_PTK	0.25
p.G140E	SIDM00890	Melanoma	GDSC	NWYTDEP	CBL_PTK	0.25
p.G140E	C32	skin	COSMIC	NWYTDEP	CBL_PTK	0.25
p.S127P	TCGA-EE-A2MF	SKCM	TCGA	NWYTDEP	CBL_PTK	0.2222
p.G124R	TCGA-EE-A2MR	SKCM	TCGA	NWYTDEP	CBL_PTK	0.1389
p.E136K	TCGA-FS-A1ZK	SKCM	TCGA	NWYTDEP	CBL_PTK	0.591
p.G140R	TCGA-MB-A8JL	SARC	TCGA	NWYTDEP	CBL_PTK	0.25
p.G140R	ACH-000586	Lung Cancer	CCLE	NWYTDEP	CBL_PTK	0.25
p.G140R	NCI-H1876	lung	COSMIC	NWYTDEP	CBL_PTK	0.25
p.P145S	DO25010	LUAD	ICGC	NWYTDEP	CBL_PTK	0.1111
p.P145S	DO37966	SKCM	ICGC	NWYTDEP	CBL_PTK	0.1111
p.T146A	DO27295	LUSC	ICGC	NWYTDEP	CBL_PTK	0.0833
p.I143N	DO220912	MELA	ICGC	NWYTDEP	CBL_PTK	0.2778
p.K132N	DO232761	PBCA	ICGC	NWYTDEP	CBL_PTK	0.6918
p.D126N	DO51282	SKCM	ICGC	NWYTDEP	CBL_PTK	0.1944
p.C137Y	DO223286	UCEC	ICGC	NWYTDEP	CBL_PTK	0.7087
p.S141R	SIDM02040	Esophageal Carcinoma	GDSC	NWYTDEP	CBL_PTK	0.2222
p.S138F	SIDM00581	Glioblastoma	GDSC	NWYTDEP	CBL_PTK	0.3056
p.S138F	ACH-000738	Brain Cancer	CCLE	NWYTDEP	CBL_PTK	0.3056
p.S138F	GB-1	central_nervous_system	COSMIC	NWYTDEP	CBL_PTK	0.3056
p.W124R	23132-87	stomach	COSMIC	NWYTDEP	CBL_PTK	0.1389
p.I136F	SU-DHL-6	haematopoietic_and_lymphoid_tissue	COSMIC	NWYTDEP	CBL_PTK	0.7415
p.W146R	23132-87	stomach	COSMIC	NWYTDEP	CBL_PTK	0.0833
p.G121E	C32	skin	COSMIC	NWYTDEP	CBL_PTK	0.0556
p.G121R	NCI-H1876	lung	COSMIC	NWYTDEP	CBL_PTK	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H9P2	Chondrolectin	CBL_PTK	131:137	NWYTDEP	CBL	0.9728	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NWYTDEP

Degron related mutations and impact score

Drug responses associated with CHODL mutations

All proteins holding degron of NWYTDEP