FUNCTION: Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Invol...
FUNCTION: Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known. {ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:24752605}.
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GO - Biological processes (BP):
activation of GTPase activity [GO:0090630]; autophagy [GO:0006914]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]...
activation of GTPase activity [GO:0090630]; autophagy [GO:0006914]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]
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GO - Molecular function (MF):
GTPase activator activity [GO:0005096]...
GTPase activator activity [GO:0005096]
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GO - Cellular component (CC):
autophagosome [GO:0005776]; cytosol [GO:0005829]; recycling endosome [GO:0055037]...
autophagosome [GO:0005776]; cytosol [GO:0005829]; recycling endosome [GO:0055037]
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