DegronMD

Uniprot ID: Q9HA65

Source protein: TBC1 domain family member 17

Source gene: TBC1D17

Class: DEG_SCF_FBW7_1

Location: 618:624

E3 ligase: FBXW7

DEGRON score: 0.9807

ASA_SCORE: 94.9143

COIL: 0.982

CONS_SCORE: 0.3033

DSS_SCORE: 0.8999

HELIX: 0.0086

FCONS_SCORE: 0.9643

RIG_SCORE: 0.4518

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P609S	TCGA-FW-A3R5	SKCM	TCGA	PPTPPPS	DEG_SCF_FBW7_1	0.0833
p.R616W	ACH-000568	Breast Cancer	CCLE	PPTPPPS	DEG_SCF_FBW7_1	0.2778
p.S633N	ACH-001145	Ovarian Cancer	CCLE	PPTPPPS	DEG_SCF_FBW7_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HA65	TBC1 domain family member 17	DEG_SCF_FBW7_1	618:624	PPTPPPS	FBXW7	0.9807	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons