DegronMD - Q9HAP2(MLXIP)

MLXIP

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q364H	TCGA-AP-A051	UCEC	TCGA	SASAPVPDP	DEG_COP1_1	350:358	Mutation rewiring degron network	0.1667
p.Q364H	DO42673	UCEC	ICGC	SASAPVPDP	DEG_COP1_1	350:358	Mutation rewiring degron network	0.1667
p.S345F	TCGA-EE-A2GJ	SKCM	TCGA	SASAPVPDP	DEG_COP1_1	350:358	Mutation rewiring degron network	0.1944
p.S345F	DO37746	SKCM	ICGC	SASAPVPDP	DEG_COP1_1	350:358	Mutation rewiring degron network	0.1944
p.S345T	DO36556	READ	ICGC	SASAPVPDP	DEG_COP1_1	350:358	Mutation rewiring degron network	0.1944
p.N359I	DO229467	SKCA	ICGC	SASAPVPDP	DEG_COP1_1	350:358	Mutation rewiring degron network	0.3056
p.P361L	DO37946	SKCM	ICGC	SASAPVPDP	DEG_COP1_1	350:358	Mutation rewiring degron network	0.25
p.V355E	SIDM01177	B-Lymphoblastic Leukemia	GDSC	SASAPVPDP	DEG_COP1_1	350:358	Mutation altering degron motif	0.7693
p.V355E	SUP-B8	haematopoietic and lymphoid tissue	COSMIC	SASAPVPDP	DEG_COP1_1	350:358	Mutation altering degron motif	0.7693
p.A351T	SIDM00153	T-Lymphoblastic Leukemia	GDSC	SASAPVPDP	DEG_COP1_1	350:358	Mutation altering degron motif	0.6028
p.A351T	ACH-000964	Leukemia	CCLE	SASAPVPDP	DEG_COP1_1	350:358	Mutation altering degron motif	0.6028
p.A363V	LNCaP-Clone-FGC	prostate	COSMIC	SASAPVPDP	DEG_COP1_1	350:358	Mutation rewiring degron network	0.1944
p.T365I	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	SASAPVPDP	DEG_COP1_1	350:358	Mutation rewiring degron network	0.1389
p.N355S	NCI-H2085	lung	COSMIC	SASAPVPDP	DEG_COP1_1	350:358	Mutation altering degron motif	0.7069

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*NOTE: the Kaplan plots were collected from OncoLnc