DegronMD

Uniprot ID: Q9HAP2

Source protein: MLX-interacting protein

Source gene: MLXIP

Class: DEG_COP1_1

Location: 350:358

E3 ligase: COP1

DEGRON score: 0.9891

ASA_SCORE: 77.0222

COIL: 0.9239

CONS_SCORE: 0.3586

DSS_SCORE: 0.5823

HELIX: 0.0469

FCONS_SCORE: 0.9532

RIG_SCORE: 0.5845

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q364H	TCGA-AP-A051	UCEC	TCGA	SASAPVPDP	DEG_COP1_1	0.1667
p.Q364H	DO42673	UCEC	ICGC	SASAPVPDP	DEG_COP1_1	0.1667
p.S345F	TCGA-EE-A2GJ	SKCM	TCGA	SASAPVPDP	DEG_COP1_1	0.1944
p.S345F	DO37746	SKCM	ICGC	SASAPVPDP	DEG_COP1_1	0.1944
p.S345T	DO36556	READ	ICGC	SASAPVPDP	DEG_COP1_1	0.1944
p.N359I	DO229467	SKCA	ICGC	SASAPVPDP	DEG_COP1_1	0.3056
p.P361L	DO37946	SKCM	ICGC	SASAPVPDP	DEG_COP1_1	0.25
p.V355E	SIDM01177	B-Lymphoblastic Leukemia	GDSC	SASAPVPDP	DEG_COP1_1	0.7693
p.V355E	SUP-B8	haematopoietic_and_lymphoid_tissue	COSMIC	SASAPVPDP	DEG_COP1_1	0.7693
p.A351T	SIDM00153	T-Lymphoblastic Leukemia	GDSC	SASAPVPDP	DEG_COP1_1	0.6028
p.A351T	ACH-000964	Leukemia	CCLE	SASAPVPDP	DEG_COP1_1	0.6028
p.A363V	LNCaP-Clone-FGC	prostate	COSMIC	SASAPVPDP	DEG_COP1_1	0.1944
p.T365I	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	SASAPVPDP	DEG_COP1_1	0.1389
p.N355S	NCI-H2085	lung	COSMIC	SASAPVPDP	DEG_COP1_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HAP2	MLX-interacting protein	DEG_COP1_1	350:358	SASAPVPDP	COP1	0.9891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons