DegronMD - Q9HAT8(PELI2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T64M	TCGA-A6-5665	COAD	TCGA	VISTPQAS	DEG_SCF_FBW7_1	61:68	Mutation altering degron motif	0.8534
p.T64M	DO9756	COAD	ICGC	VISTPQAS	DEG_SCF_FBW7_1	61:68	Mutation altering degron motif	0.8534
p.I71S	TCGA-ER-A19L	SKCM	TCGA	VISTPQAS	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.25
p.I71S	DO37587	SKCM	ICGC	VISTPQAS	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.25
p.I71M	TCGA-K4-A3WS	BLCA	TCGA	VISTPQAS	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.25
p.I71M	DO480	BLCA	ICGC	VISTPQAS	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.25
p.S57I	TCGA-LN-A49P	ESCA	TCGA	VISTPQAS	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.2222
p.C73R	TCGA-Y8-A8RY	KIRP	TCGA	VISTPQAS	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.1944
p.C73R	DO51572	KIRP	ICGC	VISTPQAS	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.1944
p.G53D	DO222884	COCA	ICGC	VISTPQAS	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.1111
p.G53D	DO231447	THCA	ICGC	VISTPQAS	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.1111
p.S57R	DO229213	THCA	ICGC	VISTPQAS	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.2222
p.S57G	SIDM00498	Colorectal Carcinoma	GDSC	VISTPQAS	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.2222
p.S57G	ACH-000970	Colon/Colorectal Cancer	CCLE	VISTPQAS	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.2222
p.S57G	SNU-C5	large intestine	COSMIC	VISTPQAS	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.2222
p.P56A	SIDM00380	Acute Myeloid Leukemia	GDSC	VISTPQAS	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.1944
p.P56A	ACH-000373	Leukemia	CCLE	VISTPQAS	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.1944
p.P56A	SKM-1	haematopoietic and lymphoid tissue	COSMIC	VISTPQAS	DEG_SCF_FBW7_1	61:68	Mutation rewiring degron network	0.1944

Kaplan plot for PELI2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PELI2

UniProt ID: Q9HAT8

Entrez ID: 57161

Protein name: E3 ubiquitin-protein ligase pellino homolog 2 (Pellino-2) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase pellino homolog 2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PELI2 in