DegronMD

Uniprot ID: Q9HAT8

Source protein: E3 ubiquitin-protein ligase pellino homolog 2

Source gene: PELI2

Class: DEG_SCF_FBW7_1

Location: 61:68

E3 ligase: FBXW7

DEGRON score: 0.8806

ASA_SCORE: 56.6875

COIL: 0.5249

CONS_SCORE: 0.5424

DSS_SCORE: 0.4077

HELIX: 0.2309

FCONS_SCORE: 1.0719

RIG_SCORE: 0.7592

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T64M	TCGA-A6-5665	COAD	TCGA	VISTPQAS	DEG_SCF_FBW7_1	0.8534
p.T64M	DO9756	COAD	ICGC	VISTPQAS	DEG_SCF_FBW7_1	0.8534
p.I71S	TCGA-ER-A19L	SKCM	TCGA	VISTPQAS	DEG_SCF_FBW7_1	0.25
p.I71S	DO37587	SKCM	ICGC	VISTPQAS	DEG_SCF_FBW7_1	0.25
p.I71M	TCGA-K4-A3WS	BLCA	TCGA	VISTPQAS	DEG_SCF_FBW7_1	0.25
p.I71M	DO480	BLCA	ICGC	VISTPQAS	DEG_SCF_FBW7_1	0.25
p.S57I	TCGA-LN-A49P	ESCA	TCGA	VISTPQAS	DEG_SCF_FBW7_1	0.2222
p.C73R	TCGA-Y8-A8RY	KIRP	TCGA	VISTPQAS	DEG_SCF_FBW7_1	0.1944
p.C73R	DO51572	KIRP	ICGC	VISTPQAS	DEG_SCF_FBW7_1	0.1944
p.G53D	DO222884	COCA	ICGC	VISTPQAS	DEG_SCF_FBW7_1	0.1111
p.G53D	DO231447	THCA	ICGC	VISTPQAS	DEG_SCF_FBW7_1	0.1111
p.S57R	DO229213	THCA	ICGC	VISTPQAS	DEG_SCF_FBW7_1	0.2222
p.S57G	SIDM00498	Colorectal Carcinoma	GDSC	VISTPQAS	DEG_SCF_FBW7_1	0.2222
p.S57G	ACH-000970	Colon/Colorectal Cancer	CCLE	VISTPQAS	DEG_SCF_FBW7_1	0.2222
p.S57G	SNU-C5	large_intestine	COSMIC	VISTPQAS	DEG_SCF_FBW7_1	0.2222
p.P56A	SIDM00380	Acute Myeloid Leukemia	GDSC	VISTPQAS	DEG_SCF_FBW7_1	0.1944
p.P56A	ACH-000373	Leukemia	CCLE	VISTPQAS	DEG_SCF_FBW7_1	0.1944
p.P56A	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	VISTPQAS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HAT8	E3 ubiquitin-protein ligase pellino homolog 2	DEG_SCF_FBW7_1	61:68	VISTPQAS	FBXW7	0.8806	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons