DegronMD - Q9HAV7(GRPEL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H202N	TCGA-05-4424	LUAD	TCGA	LRPALVGVV	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.2222
p.H202N	DO23672	LUAD	ICGC	LRPALVGVV	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.2222
p.G203E	TCGA-A5-A0G2	UCEC	TCGA	LRPALVGVV	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.25
p.G203E	DO41235	UCEC	ICGC	LRPALVGVV	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.25
p.R204C	TCGA-AA-3821	COAD	TCGA	LRPALVGVV	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.2778
p.R204C	TCGA-AP-A0LM	UCEC	TCGA	LRPALVGVV	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.2778
p.R204C	DO9314	COAD	ICGC	LRPALVGVV	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.2778
p.R204C	DO43306	UCEC	ICGC	LRPALVGVV	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.2778
p.G203V	TCGA-AP-A051	UCEC	TCGA	LRPALVGVV	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.25
p.G203V	DO42673	UCEC	ICGC	LRPALVGVV	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.25
p.A209T	TCGA-IB-7651	PAAD	TCGA	LRPALVGVV	DEG_APCC_DBOX_1	206:214	Mutation altering degron motif	0.6028
p.A209T	DO46657	PAAD	ICGC	LRPALVGVV	DEG_APCC_DBOX_1	206:214	Mutation altering degron motif	0.6028
p.R204H	DO52456	COCA	ICGC	LRPALVGVV	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.2778
p.P208T	DO228948	LICA	ICGC	LRPALVGVV	DEG_APCC_DBOX_1	206:214	Mutation altering degron motif	0.5919
p.G203W	DO229061	LICA	ICGC	LRPALVGVV	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.25
p.K215N	DO232761	PBCA	ICGC	LRPALVGVV	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.3056

Kaplan plot for GRPEL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GRPEL1

UniProt ID: Q9HAV7

Entrez ID: 80273

Protein name: GrpE protein homolog 1, mitochondrial (HMGE) (Mt-GrpE#1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GRPEL1 in