DegronMD

Uniprot ID: Q9HAV7

Source protein: GrpE protein homolog 1, mitochondrial

Source gene: GRPEL1

Class: DEG_APCC_DBOX_1

Location: 206:214

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.883

ASA_SCORE: 46.3556

COIL: 0.3304

CONS_SCORE: 0.7172

DSS_SCORE: 0.3939

HELIX: 0.0127

FCONS_SCORE: 1.3324

RIG_SCORE: 0.8278

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H202N	TCGA-05-4424	LUAD	TCGA	LRPALVGVV	DEG_APCC_DBOX_1	0.2222
p.H202N	DO23672	LUAD	ICGC	LRPALVGVV	DEG_APCC_DBOX_1	0.2222
p.G203E	TCGA-A5-A0G2	UCEC	TCGA	LRPALVGVV	DEG_APCC_DBOX_1	0.25
p.G203E	DO41235	UCEC	ICGC	LRPALVGVV	DEG_APCC_DBOX_1	0.25
p.R204C	TCGA-AA-3821	COAD	TCGA	LRPALVGVV	DEG_APCC_DBOX_1	0.2778
p.R204C	TCGA-AP-A0LM	UCEC	TCGA	LRPALVGVV	DEG_APCC_DBOX_1	0.2778
p.R204C	DO9314	COAD	ICGC	LRPALVGVV	DEG_APCC_DBOX_1	0.2778
p.R204C	DO43306	UCEC	ICGC	LRPALVGVV	DEG_APCC_DBOX_1	0.2778
p.G203V	TCGA-AP-A051	UCEC	TCGA	LRPALVGVV	DEG_APCC_DBOX_1	0.25
p.G203V	DO42673	UCEC	ICGC	LRPALVGVV	DEG_APCC_DBOX_1	0.25
p.A209T	TCGA-IB-7651	PAAD	TCGA	LRPALVGVV	DEG_APCC_DBOX_1	0.6028
p.A209T	DO46657	PAAD	ICGC	LRPALVGVV	DEG_APCC_DBOX_1	0.6028
p.R204H	DO52456	COCA	ICGC	LRPALVGVV	DEG_APCC_DBOX_1	0.2778
p.P208T	DO228948	LICA	ICGC	LRPALVGVV	DEG_APCC_DBOX_1	0.5919
p.G203W	DO229061	LICA	ICGC	LRPALVGVV	DEG_APCC_DBOX_1	0.25
p.K215N	DO232761	PBCA	ICGC	LRPALVGVV	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HAV7	GrpE protein homolog 1, mitochondrial	DEG_APCC_DBOX_1	206:214	LRPALVGVV	APC,CDC20,FZR1	0.883	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons