DegronMD - Q9HB09(BCL2L12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A123S	DO229027	LICA	ICGC	PVPTPPRS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.2778
p.L126F	DO47957	STAD	ICGC	PVPTPPRS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.1944
p.P122H	SIDM00150	Colorectal Carcinoma	GDSC	PVPTPPRS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.3056
p.P122H	ACH-000969	Colon/Colorectal Cancer	CCLE	PVPTPPRS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.3056
p.P122H	KM12	large intestine	COSMIC	PVPTPPRS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.3056
p.P122S	SIDM01409	Bladder Carcinoma	GDSC	PVPTPPRS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.3056
p.P121H	KM12	large intestine	COSMIC	PVPTPPRS	DEG_SCF_FBW7_1	114:121	Mutation altering degron motif	0.7694
p.S123F	A2058	skin	COSMIC	PVPTPPRS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.2778
p.P116S	A2058	skin	COSMIC	PVPTPPRS	DEG_SCF_FBW7_1	114:121	Mutation altering degron motif	0.5641
p.Q115P	NCI-H2342	lung	COSMIC	PVPTPPRS	DEG_SCF_FBW7_1	114:121	Mutation altering degron motif	0.7035
p.L125P	LN-229	central nervous system	COSMIC	PVPTPPRS	DEG_SCF_FBW7_1	114:121	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons