DegronMD

Uniprot ID: Q9HB09

Source protein: Bcl-2-like protein 12

Source gene: BCL2L12

Class: DEG_SCF_FBW7_1

Location: 114:121

E3 ligase: FBXW7

DEGRON score: 0.7638

ASA_SCORE: 97.925

COIL: 0.9741

CONS_SCORE: 0.7447

DSS_SCORE: 0.763

HELIX: 0.0085

FCONS_SCORE: 1.0784

RIG_SCORE: 0.5853

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P121H	KM12	large_intestine	COSMIC	PVPTPPRS	DEG_SCF_FBW7_1	0.7694
p.Q115P	NCI-H2342	lung	COSMIC	PVPTPPRS	DEG_SCF_FBW7_1	0.7035
p.P116S	A2058	skin	COSMIC	PVPTPPRS	DEG_SCF_FBW7_1	0.5641
p.P122H	SIDM00150	Colorectal Carcinoma	GDSC	PVPTPPRS	DEG_SCF_FBW7_1	0.3056
p.P122H	ACH-000969	Colon/Colorectal Cancer	CCLE	PVPTPPRS	DEG_SCF_FBW7_1	0.3056
p.P122H	KM12	large_intestine	COSMIC	PVPTPPRS	DEG_SCF_FBW7_1	0.3056
p.P122S	SIDM01409	Bladder Carcinoma	GDSC	PVPTPPRS	DEG_SCF_FBW7_1	0.3056
p.A123S	DO229027	LICA	ICGC	PVPTPPRS	DEG_SCF_FBW7_1	0.2778
p.S123F	A2058	skin	COSMIC	PVPTPPRS	DEG_SCF_FBW7_1	0.2778
p.L125P	LN-229	central_nervous_system	COSMIC	PVPTPPRS	DEG_SCF_FBW7_1	0.2222
p.L126F	DO47957	STAD	ICGC	PVPTPPRS	DEG_SCF_FBW7_1	0.1944

Showing 1 to 11 of 11 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HB09	Bcl-2-like protein 12	DEG_SCF_FBW7_1	114:121	PVPTPPRS	FBXW7	0.7638	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons