DegronMD - Q9HB71(CACYBP)

CACYBP

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T72M	TCGA-19-1787	GBM	TCGA	KPAAVVAPI	DEG_SIAH_1	59:67	Mutation blocking phosphorylation signal	0.6389
p.S76G	TCGA-94-8490	LUSC	TCGA	KPAAVVAPI	DEG_SIAH_1	59:67	Mutation rewiring degron network	0.0833
p.A62V	TCGA-AP-A059	UCEC	TCGA	KPAAVVAPI	DEG_SIAH_1	59:67	Mutation altering degron motif	0.6936
p.T69M	TCGA-B5-A3FC	UCEC	TCGA	KPAAVVAPI	DEG_SIAH_1	59:67	Mutation blocking phosphorylation signal	0.7222
p.N77K	TCGA-CA-6717	COAD	TCGA	KPAAVVAPI	DEG_SIAH_1	59:67	Mutation rewiring degron network	0.0556
p.N77K	TCGA-EO-A22R	UCEC	TCGA	KPAAVVAPI	DEG_SIAH_1	59:67	Mutation rewiring degron network	0.0556
p.L55F	TCGA-CV-7568	HNSC	TCGA	KPAAVVAPI	DEG_SIAH_1	59:67	Mutation rewiring degron network	0.2222
p.E58K	TCGA-G2-AA3B	BLCA	TCGA	KPAAVVAPI	DEG_SIAH_1	59:67	Mutation rewiring degron network	0.3056
p.T49A	DO233634	GACA	ICGC	KPAAVVAPI	DEG_SIAH_1	59:67	Mutation rewiring degron network	0.0556
p.T49A	DO38192	STAD	ICGC	KPAAVVAPI	DEG_SIAH_1	59:67	Mutation rewiring degron network	0.0556
p.L72R	DO45175	LIRI	ICGC	KPAAVVAPI	DEG_SIAH_1	59:67	Mutation blocking phosphorylation signal	0.6389
p.R68M	DO37523	SKCM	ICGC	KPAAVVAPI	DEG_SIAH_1	59:67	Mutation blocking phosphorylation signal	0.75
p.K75E	ACH-000721	Breast Cancer	CCLE	KPAAVVAPI	DEG_SIAH_1	59:67	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc