DegronMD

Uniprot ID: Q9HB71

Source protein: Calcyclin-binding protein

Source gene: CACYBP

Class: DEG_SIAH_1

Location: 59:67

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9937

ASA_SCORE: 82.6

COIL: 0.8161

CONS_SCORE: 0.4934

DSS_SCORE: 0.2649

HELIX: 0.0723

FCONS_SCORE: 0.8954

RIG_SCORE: 0.8031

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T72M	TCGA-19-1787	GBM	TCGA	KPAAVVAPI	DEG_SIAH_1	0.6389
p.S76G	TCGA-94-8490	LUSC	TCGA	KPAAVVAPI	DEG_SIAH_1	0.0833
p.A62V	TCGA-AP-A059	UCEC	TCGA	KPAAVVAPI	DEG_SIAH_1	0.6936
p.T69M	TCGA-B5-A3FC	UCEC	TCGA	KPAAVVAPI	DEG_SIAH_1	0.7222
p.N77K	TCGA-CA-6717	COAD	TCGA	KPAAVVAPI	DEG_SIAH_1	0.0556
p.N77K	TCGA-EO-A22R	UCEC	TCGA	KPAAVVAPI	DEG_SIAH_1	0.0556
p.L55F	TCGA-CV-7568	HNSC	TCGA	KPAAVVAPI	DEG_SIAH_1	0.2222
p.E58K	TCGA-G2-AA3B	BLCA	TCGA	KPAAVVAPI	DEG_SIAH_1	0.3056
p.T49A	DO233634	GACA	ICGC	KPAAVVAPI	DEG_SIAH_1	0.0556
p.T49A	DO38192	STAD	ICGC	KPAAVVAPI	DEG_SIAH_1	0.0556
p.L72R	DO45175	LIRI	ICGC	KPAAVVAPI	DEG_SIAH_1	0.6389
p.R68M	DO37523	SKCM	ICGC	KPAAVVAPI	DEG_SIAH_1	0.75
p.K75E	ACH-000721	Breast Cancer	CCLE	KPAAVVAPI	DEG_SIAH_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HB71	Calcyclin-binding protein	DEG_SIAH_1	59:67	KPAAVVAPI	SIAH1,SIAH2,SIAH3	0.9937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons