RRAGC
UniProt ID: Q9HB90
Entrez ID: 64121
Protein name: Ras-related GTP-binding protein C (Rag C) (RagC) (EC 3.6.5.-) (GTPase-interacting protein 2) (TIB929)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:27234373, PubMed:24095279). Forms heterodimeric Rag complexes with RRAGA or RRAGB and cycles between ...
FUNCTION: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:27234373, PubMed:24095279). Forms heterodimeric Rag complexes with RRAGA or RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form (PubMed:24095279). In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:27234373, PubMed:24095279). This is a crucial step in the activation of the TOR signaling cascade by amino acids (PubMed:20381137, PubMed:27234373, PubMed:24095279). {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:27234373}.
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GO - Biological processes (BP):
apoptotic process [GO:0006915]; cellular protein localization [GO:0034613]; cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to starvation [GO:0009267]; positive regulation of TOR signaling [GO:0032008]; regulation of a...
apoptotic process [GO:0006915]; cellular protein localization [GO:0034613]; cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to starvation [GO:0009267]; positive regulation of TOR signaling [GO:0032008]; regulation of autophagy [GO:0010506]; regulation of TORC1 signaling [GO:1903432]; regulation of TOR signaling [GO:0032006]; response to amino acid [GO:0043200]; RNA splicing [GO:0008380]; small GTPase mediated signal transduction [GO:0007264]; transcription, DNA-templated [GO:0006351]
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GO - Molecular function (MF):
GDP binding [GO:0019003]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; GTP binding [GO:0005525]; magnesium ion binding [GO:0000287]; protein heterodimerization activity [GO:0046982]...
GDP binding [GO:0019003]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; GTP binding [GO:0005525]; magnesium ion binding [GO:0000287]; protein heterodimerization activity [GO:0046982]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gtr1-Gtr2 GTPase complex [GO:1990131]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]...
cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gtr1-Gtr2 GTPase complex [GO:1990131]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
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RRAGC
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*NOTE: the Kaplan plots were collected from OncoLnc