DegronMD

Uniprot ID: Q9HB90

Source protein: Ras-related GTP-binding protein C

Source gene: RRAGC

Class: DEG_APCC_DBOX_1

Location: 62:70

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7418

ASA_SCORE: 29.8222

COIL: 0.3923

CONS_SCORE: 0.6397

DSS_SCORE: 0.527

HELIX: 0.0128

FCONS_SCORE: 1.3213

RIG_SCORE: 0.7982

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V80G	DO27805	MALY	ICGC	PRILLMGLR	DEG_APCC_DBOX_1	0.0556
p.S75F	DO27781	MALY	ICGC	PRILLMGLR	DEG_APCC_DBOX_1	0.6389
p.S75F	ACH-000656	Lymphoma	CCLE	PRILLMGLR	DEG_APCC_DBOX_1	0.6389
p.V80A	DO27785	MALY	ICGC	PRILLMGLR	DEG_APCC_DBOX_1	0.0556
p.G73D	DO52670	MALY	ICGC	PRILLMGLR	DEG_APCC_DBOX_1	0.25
p.K74T	DO228889	MALY	ICGC	PRILLMGLR	DEG_APCC_DBOX_1	0.3333
p.I77T	DO229272	THCA	ICGC	PRILLMGLR	DEG_APCC_DBOX_1	0.1389
p.P54S	ACH-000034	Primary	CCLE	PRILLMGLR	DEG_APCC_DBOX_1	0.1111
p.P54L	ACH-000051	Sarcoma	CCLE	PRILLMGLR	DEG_APCC_DBOX_1	0.1111
p.D58E	ACH-000434	Lung Cancer	CCLE	PRILLMGLR	DEG_APCC_DBOX_1	0.2222
p.G56D	ACH-000847	Gastric Cancer	CCLE	PRILLMGLR	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HB90	Ras-related GTP-binding protein C	DEG_APCC_DBOX_1	62:70	PRILLMGLR	APC,CDC20,FZR1	0.7418	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons