DegronMD - Q9HBF4(ZFYVE1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R391Q	TCGA-2W-A8YY	CESC	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.0833
p.R391Q	TCGA-BR-6457	STAD	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.0833
p.R391Q	DO223732	CESC	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.0833
p.R391Q	DO228123	EOPC	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.0833
p.R391Q	DO233245	GACA	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.0833
p.R391Q	DO38759	STAD	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.0833
p.R388C	TCGA-A5-A0G9	UCEC	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.1667
p.R388C	DO42304	UCEC	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.1667
p.P367S	TCGA-AD-6895	COAD	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.1389
p.P367S	DO8938	COAD	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.1389
p.Q380H	TCGA-AP-A0LM	UCEC	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation altering degron motif	0.647
p.Q380H	DO43306	UCEC	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation altering degron motif	0.647
p.R375W	TCGA-CA-6717	COAD	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation altering degron motif	0.8634
p.R375W	DO8264	COAD	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation altering degron motif	0.8634
p.R375W	ACH-000975	Lung Cancer	CCLE	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation altering degron motif	0.8634
p.R391W	TCGA-CD-8531	STAD	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.0833
p.R391W	DO47877	STAD	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.0833
p.P368L	TCGA-D3-A2JK	SKCM	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.1667
p.P368L	DO37619	SKCM	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.1667
p.P367H	TCGA-EY-A215	UCEC	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.1389
p.P367H	DO42665	UCEC	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.1389
p.T369M	TCGA-G2-A3IB	BLCA	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation blocking phosphorylation signal	0.6389
p.T369M	DO512	BLCA	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation blocking phosphorylation signal	0.6389
p.R376C	SIDM00602	Gastric Carcinoma	GDSC	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation altering degron motif	0.719
p.R376C	ACH-000919	Gastric Cancer	CCLE	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation altering degron motif	0.719
p.R376C	IM-95	stomach	COSMIC	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation altering degron motif	0.719
p.P390S	SIDM00245	Small Cell Lung Carcinoma	GDSC	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.1111
p.P390S	ACH-001131	Skin Cancer	CCLE	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.1111
p.P390S	ACH-001958	lung	CCLE	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.1111
p.P390S	MS-1	lung	COSMIC	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.1111
p.R388H	SIDM00500	Colorectal Carcinoma	GDSC	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.1667
p.R388H	ACH-000959	Colon/Colorectal Cancer	CCLE	LRRALEQLL	DEG_APCC_DBOX_1	374:382	Mutation rewiring degron network	0.1667

Kaplan plot for ZFYVE1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZFYVE1

UniProt ID: Q9HBF4

Entrez ID: 53349

Protein name: Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (SR3) (Tandem FYVE fingers-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZFYVE1 in