DegronMD

Uniprot ID: Q9HBF4

Source protein: Zinc finger FYVE domain-containing protein 1

Source gene: ZFYVE1

Class: DEG_APCC_DBOX_1

Location: 374:382

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5796

ASA_SCORE: 53.1556

COIL: 0.0214

CONS_SCORE: 0.5287

DSS_SCORE: 0.463

HELIX: 0.9769

FCONS_SCORE: 0.8136

RIG_SCORE: 0.8054

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R375W	TCGA-CA-6717	COAD	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	0.8634
p.R375W	DO8264	COAD	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	0.8634
p.R375W	ACH-000975	Lung Cancer	CCLE	LRRALEQLL	DEG_APCC_DBOX_1	0.8634
p.R376C	SIDM00602	Gastric Carcinoma	GDSC	LRRALEQLL	DEG_APCC_DBOX_1	0.719
p.R376C	ACH-000919	Gastric Cancer	CCLE	LRRALEQLL	DEG_APCC_DBOX_1	0.719
p.R376C	IM-95	stomach	COSMIC	LRRALEQLL	DEG_APCC_DBOX_1	0.719
p.Q380H	TCGA-AP-A0LM	UCEC	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	0.647
p.Q380H	DO43306	UCEC	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	0.647
p.T369M	TCGA-G2-A3IB	BLCA	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	0.6389
p.T369M	DO512	BLCA	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	0.6389
p.R388C	TCGA-A5-A0G9	UCEC	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	0.1667
p.R388C	DO42304	UCEC	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	0.1667
p.P368L	TCGA-D3-A2JK	SKCM	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	0.1667
p.P368L	DO37619	SKCM	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	0.1667
p.R388H	SIDM00500	Colorectal Carcinoma	GDSC	LRRALEQLL	DEG_APCC_DBOX_1	0.1667
p.R388H	ACH-000959	Colon/Colorectal Cancer	CCLE	LRRALEQLL	DEG_APCC_DBOX_1	0.1667
p.P367S	TCGA-AD-6895	COAD	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	0.1389
p.P367S	DO8938	COAD	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	0.1389
p.P367H	TCGA-EY-A215	UCEC	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	0.1389
p.P367H	DO42665	UCEC	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	0.1389
p.P390S	SIDM00245	Small Cell Lung Carcinoma	GDSC	LRRALEQLL	DEG_APCC_DBOX_1	0.1111
p.P390S	ACH-001131	Skin Cancer	CCLE	LRRALEQLL	DEG_APCC_DBOX_1	0.1111
p.P390S	ACH-001958	lung	CCLE	LRRALEQLL	DEG_APCC_DBOX_1	0.1111
p.P390S	MS-1	lung	COSMIC	LRRALEQLL	DEG_APCC_DBOX_1	0.1111
p.R391Q	TCGA-2W-A8YY	CESC	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	0.0833

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Drug responses associated with ZFYVE1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LRRALEQLL

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HBF4	Zinc finger FYVE domain-containing protein 1	DEG_APCC_DBOX_1	374:382	LRRALEQLL	APC,CDC20,FZR1	0.5796	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRRALEQLL

Degron related mutations and impact score

Drug responses associated with ZFYVE1 mutations

All proteins holding degron of LRRALEQLL