DegronMD

Uniprot ID: Q9HBF4

Source protein: Zinc finger FYVE domain-containing protein 1

Source gene: ZFYVE1

Class: DEG_APCC_DBOX_1

Location: 374:382

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5796

ASA_SCORE: 53.1556

COIL: 0.0214

CONS_SCORE: 0.5287

DSS_SCORE: 0.463

HELIX: 0.9769

FCONS_SCORE: 0.8136

RIG_SCORE: 0.8054

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R391Q	TCGA-2W-A8YY	CESC	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	0.0833
p.R391Q	TCGA-BR-6457	STAD	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	0.0833
p.R391Q	DO223732	CESC	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	0.0833
p.R391Q	DO228123	EOPC	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	0.0833
p.R391Q	DO233245	GACA	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	0.0833
p.R391Q	DO38759	STAD	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	0.0833
p.R388C	TCGA-A5-A0G9	UCEC	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	0.1667
p.R388C	DO42304	UCEC	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	0.1667
p.P367S	TCGA-AD-6895	COAD	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	0.1389
p.P367S	DO8938	COAD	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	0.1389
p.Q380H	TCGA-AP-A0LM	UCEC	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	0.647
p.Q380H	DO43306	UCEC	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	0.647
p.R375W	TCGA-CA-6717	COAD	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	0.8634
p.R375W	DO8264	COAD	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	0.8634
p.R375W	ACH-000975	Lung Cancer	CCLE	LRRALEQLL	DEG_APCC_DBOX_1	0.8634
p.R391W	TCGA-CD-8531	STAD	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	0.0833
p.R391W	DO47877	STAD	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	0.0833
p.P368L	TCGA-D3-A2JK	SKCM	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	0.1667
p.P368L	DO37619	SKCM	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	0.1667
p.P367H	TCGA-EY-A215	UCEC	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	0.1389
p.P367H	DO42665	UCEC	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	0.1389
p.T369M	TCGA-G2-A3IB	BLCA	TCGA	LRRALEQLL	DEG_APCC_DBOX_1	0.6389
p.T369M	DO512	BLCA	ICGC	LRRALEQLL	DEG_APCC_DBOX_1	0.6389
p.R376C	SIDM00602	Gastric Carcinoma	GDSC	LRRALEQLL	DEG_APCC_DBOX_1	0.719
p.R376C	ACH-000919	Gastric Cancer	CCLE	LRRALEQLL	DEG_APCC_DBOX_1	0.719
p.R376C	IM-95	stomach	COSMIC	LRRALEQLL	DEG_APCC_DBOX_1	0.719
p.P390S	SIDM00245	Small Cell Lung Carcinoma	GDSC	LRRALEQLL	DEG_APCC_DBOX_1	0.1111
p.P390S	ACH-001131	Skin Cancer	CCLE	LRRALEQLL	DEG_APCC_DBOX_1	0.1111
p.P390S	ACH-001958	lung	CCLE	LRRALEQLL	DEG_APCC_DBOX_1	0.1111
p.P390S	MS-1	lung	COSMIC	LRRALEQLL	DEG_APCC_DBOX_1	0.1111
p.R388H	SIDM00500	Colorectal Carcinoma	GDSC	LRRALEQLL	DEG_APCC_DBOX_1	0.1667
p.R388H	ACH-000959	Colon/Colorectal Cancer	CCLE	LRRALEQLL	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRRALEQLL

Degron related mutations and impact score

Drug responses associated with ZFYVE1 mutations

All proteins holding degron of LRRALEQLL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HBF4	Zinc finger FYVE domain-containing protein 1	DEG_APCC_DBOX_1	374:382	LRRALEQLL	APC,CDC20,FZR1	0.5796	More...