DegronMD - Q9HBI1(PARVB)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R58I	TCGA-19-5956	GBM	TCGA	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.8102
p.R58I	DO13863	GBM	ICGC	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.8102
p.L48V	TCGA-DF-A2KU	UCEC	TCGA	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.0556
p.L48V	DO223286	UCEC	ICGC	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.0556
p.W59C	DO10060	COAD	ICGC	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.7
p.A67V	DO227657	COCA	ICGC	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2222
p.A67V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2222
p.A67V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2222
p.K48E	DO229005	COCA	ICGC	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.0556
p.A49D	DO233918	GACA	ICGC	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.0833
p.I70V	DO223682	LGG	ICGC	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1389
p.D57Y	DO229053	LICA	ICGC	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.3056
p.V55I	DO229234	THCA	ICGC	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.25
p.K50N	DO43907	UCEC	ICGC	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1111
p.A49V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.0833
p.A49V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.0833
p.A49V	ACH-000995	Leukemia	CCLE	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.0833
p.A49V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.0833
p.K50E	ACH-000922	Leukemia	CCLE	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1111
p.K50E	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1111
p.E67G	ACH-001655	Endometrial/Uterine Cancer	CCLE	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2222
p.E67G	SKN	soft tissue	COSMIC	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2222
p.L63M	TGBC1TKB	biliary tract	COSMIC	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.711
p.N70S	MN-60	haematopoietic and lymphoid tissue	COSMIC	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1389
p.E52G	SKN	soft tissue	COSMIC	VDVHPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1667

Kaplan plot for PARVB in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PARVB

UniProt ID: Q9HBI1

Entrez ID: 29780

Protein name: Beta-parvin (Affixin)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PARVB in