DegronMD

Uniprot ID: Q9HBI1

Source protein: Beta-parvin

Source gene: PARVB

Class: LIG_APCC_ABBA_1

Location: 58:63

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8998

ASA_SCORE: 77.4167

COIL: 0.8177

CONS_SCORE: 0.599

DSS_SCORE: 0.7302

HELIX: 0.1337

FCONS_SCORE: 0.9359

RIG_SCORE: 0.6949

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R58I	TCGA-19-5956	GBM	TCGA	VDVHPE	LIG_APCC_ABBA_1	0.8102
p.R58I	DO13863	GBM	ICGC	VDVHPE	LIG_APCC_ABBA_1	0.8102
p.L48V	TCGA-DF-A2KU	UCEC	TCGA	VDVHPE	LIG_APCC_ABBA_1	0.0556
p.L48V	DO223286	UCEC	ICGC	VDVHPE	LIG_APCC_ABBA_1	0.0556
p.W59C	DO10060	COAD	ICGC	VDVHPE	LIG_APCC_ABBA_1	0.7
p.A67V	DO227657	COCA	ICGC	VDVHPE	LIG_APCC_ABBA_1	0.2222
p.A67V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VDVHPE	LIG_APCC_ABBA_1	0.2222
p.A67V	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VDVHPE	LIG_APCC_ABBA_1	0.2222
p.K48E	DO229005	COCA	ICGC	VDVHPE	LIG_APCC_ABBA_1	0.0556
p.A49D	DO233918	GACA	ICGC	VDVHPE	LIG_APCC_ABBA_1	0.0833
p.I70V	DO223682	LGG	ICGC	VDVHPE	LIG_APCC_ABBA_1	0.1389
p.D57Y	DO229053	LICA	ICGC	VDVHPE	LIG_APCC_ABBA_1	0.3056
p.V55I	DO229234	THCA	ICGC	VDVHPE	LIG_APCC_ABBA_1	0.25
p.K50N	DO43907	UCEC	ICGC	VDVHPE	LIG_APCC_ABBA_1	0.1111
p.A49V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VDVHPE	LIG_APCC_ABBA_1	0.0833
p.A49V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VDVHPE	LIG_APCC_ABBA_1	0.0833
p.A49V	ACH-000995	Leukemia	CCLE	VDVHPE	LIG_APCC_ABBA_1	0.0833
p.A49V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VDVHPE	LIG_APCC_ABBA_1	0.0833
p.K50E	ACH-000922	Leukemia	CCLE	VDVHPE	LIG_APCC_ABBA_1	0.1111
p.K50E	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	VDVHPE	LIG_APCC_ABBA_1	0.1111
p.E67G	ACH-001655	Endometrial/Uterine Cancer	CCLE	VDVHPE	LIG_APCC_ABBA_1	0.2222
p.E67G	SKN	soft_tissue	COSMIC	VDVHPE	LIG_APCC_ABBA_1	0.2222
p.L63M	TGBC1TKB	biliary_tract	COSMIC	VDVHPE	LIG_APCC_ABBA_1	0.711
p.N70S	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	VDVHPE	LIG_APCC_ABBA_1	0.1389
p.E52G	SKN	soft_tissue	COSMIC	VDVHPE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HBI1	Beta-parvin	LIG_APCC_ABBA_1	58:63	VDVHPE	APC,CDC20,FZR1	0.8998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VDVHPE

Degron related mutations and impact score

Drug responses associated with PARVB mutations

All proteins holding degron of VDVHPE