DegronMD - Q9HBJ7(USP29)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T712A	TCGA-53-7624	LUAD	TCGA	CKENR	DEG_APCC_KENBOX_2	718:722	Mutation rewiring degron network	0.1667
p.T712A	DO25058	LUAD	ICGC	CKENR	DEG_APCC_KENBOX_2	718:722	Mutation rewiring degron network	0.1667
p.G726E	TCGA-D3-A51T	SKCM	TCGA	CKENR	DEG_APCC_KENBOX_2	718:722	Mutation rewiring degron network	0.2222
p.G726E	DO47389	SKCM	ICGC	CKENR	DEG_APCC_KENBOX_2	718:722	Mutation rewiring degron network	0.2222
p.G726E	SIDM00586	Hepatocellular Carcinoma	GDSC	CKENR	DEG_APCC_KENBOX_2	718:722	Mutation rewiring degron network	0.2222
p.G726E	ACH-000475	Liver Cancer	CCLE	CKENR	DEG_APCC_KENBOX_2	718:722	Mutation rewiring degron network	0.2222
p.G726E	huH-1	liver	COSMIC	CKENR	DEG_APCC_KENBOX_2	718:722	Mutation rewiring degron network	0.2222
p.S727F	TCGA-EO-A22X	UCEC	TCGA	CKENR	DEG_APCC_KENBOX_2	718:722	Mutation rewiring degron network	0.1944
p.S727F	DO43907	UCEC	ICGC	CKENR	DEG_APCC_KENBOX_2	718:722	Mutation rewiring degron network	0.1944
p.R722M	TCGA-FS-A1ZG	SKCM	TCGA	CKENR	DEG_APCC_KENBOX_2	718:722	Mutation altering degron motif	0.7521
p.R722M	DO37523	SKCM	ICGC	CKENR	DEG_APCC_KENBOX_2	718:722	Mutation altering degron motif	0.7521
p.P724T	TCGA-KQ-A41N	BLCA	TCGA	CKENR	DEG_APCC_KENBOX_2	718:722	Mutation rewiring degron network	0.2778
p.P724T	DO223588	BLCA	ICGC	CKENR	DEG_APCC_KENBOX_2	718:722	Mutation rewiring degron network	0.2778
p.M730I	DO229032	LICA	ICGC	CKENR	DEG_APCC_KENBOX_2	718:722	Mutation rewiring degron network	0.1111
p.R722K	DO222572	MELA	ICGC	CKENR	DEG_APCC_KENBOX_2	718:722	Mutation altering degron motif	0.6126
p.T712P	SIDM01314	Colorectal Carcinoma	GDSC	CKENR	DEG_APCC_KENBOX_2	718:722	Mutation rewiring degron network	0.1667
p.E720K	SIDM01511	Gastric Carcinoma	GDSC	CKENR	DEG_APCC_KENBOX_2	718:722	Mutation altering degron motif	0.7022
p.E720K	ACH-000746	Gastric Cancer	CCLE	CKENR	DEG_APCC_KENBOX_2	718:722	Mutation altering degron motif	0.7022
p.C718R	RPMI-2650	upper aerodigestive tract	COSMIC	CKENR	DEG_APCC_KENBOX_2	718:722	Mutation altering degron motif	0.719

Kaplan plot for USP29 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP29

UniProt ID: Q9HBJ7

Entrez ID: 57663

Protein name: Ubiquitin carboxyl-terminal hydrolase 29 (EC 3.4.19.12) (Deubiquitinating enzyme 29) (Ubiquitin thioesterase 29) (Ubiquitin-specific-processing protease 29)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP29 in