DegronMD

Uniprot ID: Q9HBJ7

Source protein: Ubiquitin carboxyl-terminal hydrolase 29

Source gene: USP29

Class: DEG_APCC_KENBOX_2

Location: 718:722

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9686

ASA_SCORE: 97

COIL: 0.732

CONS_SCORE: 0.3348

DSS_SCORE: 0.4897

HELIX: 0.1502

FCONS_SCORE: 1.0025

RIG_SCORE: 0.8115

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T712A	TCGA-53-7624	LUAD	TCGA	CKENR	DEG_APCC_KENBOX_2	0.1667
p.T712A	DO25058	LUAD	ICGC	CKENR	DEG_APCC_KENBOX_2	0.1667
p.G726E	TCGA-D3-A51T	SKCM	TCGA	CKENR	DEG_APCC_KENBOX_2	0.2222
p.G726E	DO47389	SKCM	ICGC	CKENR	DEG_APCC_KENBOX_2	0.2222
p.G726E	SIDM00586	Hepatocellular Carcinoma	GDSC	CKENR	DEG_APCC_KENBOX_2	0.2222
p.G726E	ACH-000475	Liver Cancer	CCLE	CKENR	DEG_APCC_KENBOX_2	0.2222
p.G726E	huH-1	liver	COSMIC	CKENR	DEG_APCC_KENBOX_2	0.2222
p.S727F	TCGA-EO-A22X	UCEC	TCGA	CKENR	DEG_APCC_KENBOX_2	0.1944
p.S727F	DO43907	UCEC	ICGC	CKENR	DEG_APCC_KENBOX_2	0.1944
p.R722M	TCGA-FS-A1ZG	SKCM	TCGA	CKENR	DEG_APCC_KENBOX_2	0.7521
p.R722M	DO37523	SKCM	ICGC	CKENR	DEG_APCC_KENBOX_2	0.7521
p.P724T	TCGA-KQ-A41N	BLCA	TCGA	CKENR	DEG_APCC_KENBOX_2	0.2778
p.P724T	DO223588	BLCA	ICGC	CKENR	DEG_APCC_KENBOX_2	0.2778
p.M730I	DO229032	LICA	ICGC	CKENR	DEG_APCC_KENBOX_2	0.1111
p.R722K	DO222572	MELA	ICGC	CKENR	DEG_APCC_KENBOX_2	0.6126
p.T712P	SIDM01314	Colorectal Carcinoma	GDSC	CKENR	DEG_APCC_KENBOX_2	0.1667
p.E720K	SIDM01511	Gastric Carcinoma	GDSC	CKENR	DEG_APCC_KENBOX_2	0.7022
p.E720K	ACH-000746	Gastric Cancer	CCLE	CKENR	DEG_APCC_KENBOX_2	0.7022
p.C718R	RPMI-2650	upper_aerodigestive_tract	COSMIC	CKENR	DEG_APCC_KENBOX_2	0.719

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HBJ7	Ubiquitin carboxyl-terminal hydrolase 29	DEG_APCC_KENBOX_2	718:722	CKENR	APC,CDC20,FZR1	0.9686	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons