DegronMD - Q9HC10(OTOF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1257W	TCGA-66-2793	LUSC	TCGA	SHSTGE	DEG_Kelch_Keap1_1	1261:1266	Mutation rewiring degron network	0.2222
p.G1257W	DO27334	LUSC	ICGC	SHSTGE	DEG_Kelch_Keap1_1	1261:1266	Mutation rewiring degron network	0.2222
p.V1269A	TCGA-BR-6452	STAD	TCGA	SHSTGE	DEG_Kelch_Keap1_1	1261:1266	Mutation rewiring degron network	0.25
p.G1265V	TCGA-DA-A1IA	SKCM	TCGA	SHSTGE	DEG_Kelch_Keap1_1	1261:1266	Mutation altering degron motif	0.7532
p.E1272K	TCGA-MV-A51V	BLCA	TCGA	SHSTGE	DEG_Kelch_Keap1_1	1261:1266	Mutation rewiring degron network	0.1667
p.G1257R	TCGA-PE-A5DC	BRCA	TCGA	SHSTGE	DEG_Kelch_Keap1_1	1261:1266	Mutation rewiring degron network	0.2222
p.F1267S	DO8296	COAD	ICGC	SHSTGE	DEG_Kelch_Keap1_1	1261:1266	Mutation rewiring degron network	0.3056
p.P1276T	DO228976	LICA	ICGC	SHSTGE	DEG_Kelch_Keap1_1	1261:1266	Mutation rewiring degron network	0.0556
p.T1271M	DO27951	ORCA	ICGC	SHSTGE	DEG_Kelch_Keap1_1	1261:1266	Mutation rewiring degron network	0.1944
p.A1264T	DO229542	UTCA	ICGC	SHSTGE	DEG_Kelch_Keap1_1	1261:1266	Mutation altering degron motif	0.7139
p.P1273S	SIDM00333	Endometrial Carcinoma	GDSC	SHSTGE	DEG_Kelch_Keap1_1	1261:1266	Mutation rewiring degron network	0.1389
p.P1273S	ACH-000988	Endometrial/Uterine Cancer	CCLE	SHSTGE	DEG_Kelch_Keap1_1	1261:1266	Mutation rewiring degron network	0.1389
p.P1273S	MFE-319	endometrium	COSMIC	SHSTGE	DEG_Kelch_Keap1_1	1261:1266	Mutation rewiring degron network	0.1389
p.M1271I	ACH-000296	Colon/Colorectal Cancer	CCLE	SHSTGE	DEG_Kelch_Keap1_1	1261:1266	Mutation rewiring degron network	0.1944
p.R1265S	SKN-3	upper aerodigestive tract	COSMIC	SHSTGE	DEG_Kelch_Keap1_1	1261:1266	Mutation altering degron motif	0.7427
p.R1265C	KNS-62	lung	COSMIC	SHSTGE	DEG_Kelch_Keap1_1	1261:1266	Mutation altering degron motif	0.8301
p.R1265C	Ca9-22	upper aerodigestive tract	COSMIC	SHSTGE	DEG_Kelch_Keap1_1	1261:1266	Mutation altering degron motif	0.8301

Kaplan plot for OTOF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OTOF

UniProt ID: Q9HC10

Entrez ID: 9381

Protein name: Otoferlin (Fer-1-like protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OTOF in