DegronMD

Uniprot ID: Q9HC10

Source protein: Otoferlin

Source gene: OTOF

Class: DEG_Kelch_Keap1_1

Location: 1261:1266

E3 ligase: KEAP1

DEGRON score: 0.8908

ASA_SCORE: 71.3333

COIL: 0.7593

CONS_SCORE: 0.2677

DSS_SCORE: 0.4136

HELIX: 0.0793

FCONS_SCORE: 0.9455

RIG_SCORE: 0.6582

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1257W	TCGA-66-2793	LUSC	TCGA	SHSTGE	DEG_Kelch_Keap1_1	0.2222
p.G1257W	DO27334	LUSC	ICGC	SHSTGE	DEG_Kelch_Keap1_1	0.2222
p.V1269A	TCGA-BR-6452	STAD	TCGA	SHSTGE	DEG_Kelch_Keap1_1	0.25
p.G1265V	TCGA-DA-A1IA	SKCM	TCGA	SHSTGE	DEG_Kelch_Keap1_1	0.7532
p.E1272K	TCGA-MV-A51V	BLCA	TCGA	SHSTGE	DEG_Kelch_Keap1_1	0.1667
p.G1257R	TCGA-PE-A5DC	BRCA	TCGA	SHSTGE	DEG_Kelch_Keap1_1	0.2222
p.F1267S	DO8296	COAD	ICGC	SHSTGE	DEG_Kelch_Keap1_1	0.3056
p.P1276T	DO228976	LICA	ICGC	SHSTGE	DEG_Kelch_Keap1_1	0.0556
p.T1271M	DO27951	ORCA	ICGC	SHSTGE	DEG_Kelch_Keap1_1	0.1944
p.A1264T	DO229542	UTCA	ICGC	SHSTGE	DEG_Kelch_Keap1_1	0.7139
p.P1273S	SIDM00333	Endometrial Carcinoma	GDSC	SHSTGE	DEG_Kelch_Keap1_1	0.1389
p.P1273S	ACH-000988	Endometrial/Uterine Cancer	CCLE	SHSTGE	DEG_Kelch_Keap1_1	0.1389
p.P1273S	MFE-319	endometrium	COSMIC	SHSTGE	DEG_Kelch_Keap1_1	0.1389
p.M1271I	ACH-000296	Colon/Colorectal Cancer	CCLE	SHSTGE	DEG_Kelch_Keap1_1	0.1944
p.R1265S	SKN-3	upper_aerodigestive_tract	COSMIC	SHSTGE	DEG_Kelch_Keap1_1	0.7427
p.R1265C	KNS-62	lung	COSMIC	SHSTGE	DEG_Kelch_Keap1_1	0.8301
p.R1265C	Ca9-22	upper_aerodigestive_tract	COSMIC	SHSTGE	DEG_Kelch_Keap1_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC10	Otoferlin	DEG_Kelch_Keap1_1	1261:1266	SHSTGE	KEAP1	0.8908	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons