DegronMD - Q9HC58(SLC24A3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D427N	TCGA-05-4250	LUAD	TCGA	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.1389
p.D427N	TCGA-EE-A2MU	SKCM	TCGA	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.1389
p.D427N	DO24457	LUAD	ICGC	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.1389
p.D427N	DO37436	SKCM	ICGC	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.1389
p.D431N	TCGA-33-A4WN	LUSC	TCGA	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.25
p.D431N	TCGA-FW-A3R5	SKCM	TCGA	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.25
p.D431N	DO219121	LUSC	ICGC	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.25
p.D431N	DO37406	SKCM	ICGC	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.25
p.D427H	TCGA-85-8070	LUSC	TCGA	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.1389
p.D427H	DO26581	LUSC	ICGC	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.1389
p.D431G	TCGA-85-8288	LUSC	TCGA	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.25
p.D431G	DO26963	LUSC	ICGC	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.25
p.S442L	TCGA-B5-A11Y	UCEC	TCGA	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.2778
p.S442L	TCGA-T1-A6J8	LIHC	TCGA	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.2778
p.S442L	DO219582	LIHC	ICGC	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.2778
p.S442L	DO40889	UCEC	ICGC	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.2778
p.S442L	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.2778
p.S442L	KARPAS-1106P	haematopoietic and lymphoid tissue	COSMIC	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.2778
p.P437Q	TCGA-D3-A2JP	SKCM	TCGA	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation altering degron motif	0.7035
p.P437Q	DO47407	SKCM	ICGC	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation altering degron motif	0.7035
p.D429N	TCGA-FW-A3R5	SKCM	TCGA	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.1944
p.D429N	DO37406	SKCM	ICGC	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.1944
p.P434L	TCGA-GL-6846	KIRP	TCGA	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation altering degron motif	0.6471
p.P434L	DO20808	KIRP	ICGC	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation altering degron motif	0.6471
p.E424K	TCGA-GN-A269	SKCM	TCGA	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.0556
p.E424K	DO37483	SKCM	ICGC	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.0556
p.E432Q	TCGA-ZF-AA51	BLCA	TCGA	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.2778
p.E432Q	DO219093	BLCA	ICGC	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.2778
p.P441L	DO229502	SKCA	ICGC	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.3056
p.D430N	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.2222
p.D430N	ACH-000825	Lung Cancer	CCLE	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.2222
p.D430N	HOP-92	lung	COSMIC	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.2222
p.T436A	SIDM00214	Colorectal Carcinoma	GDSC	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation altering degron motif	0.7139
p.T436A	ACH-000955	Colon/Colorectal Cancer	CCLE	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation altering degron motif	0.7139
p.T436A	SNU-407	large intestine	COSMIC	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation altering degron motif	0.7139
p.E428K	SIDM01582	Gastric Carcinoma	GDSC	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.1667
p.E428K	ACH-000507	Gastric Cancer	CCLE	PYTPFDT	DEG_SCF_FBW7_1	434:440	Mutation rewiring degron network	0.1667

Kaplan plot for SLC24A3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC24A3

UniProt ID: Q9HC58

Entrez ID: 57419

Protein name: Sodium/potassium/calcium exchanger 3 (Na(+)/K(+)/Ca(2+)-exchange protein 3) (Solute carrier family 24 member 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC24A3 in