DegronMD

Uniprot ID: Q9HC58

Source protein: Sodium/potassium/calcium exchanger 3

Source gene: SLC24A3

Class: DEG_SCF_FBW7_1

Location: 434:440

E3 ligase: FBXW7

DEGRON score: 0.9904

ASA_SCORE: 61.0714

COIL: 0.8764

CONS_SCORE: 0.3305

DSS_SCORE: 0.7491

HELIX: 0.0277

FCONS_SCORE: 1.0986

RIG_SCORE: 0.6974

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D427N	TCGA-05-4250	LUAD	TCGA	PYTPFDT	DEG_SCF_FBW7_1	0.1389
p.D427N	TCGA-EE-A2MU	SKCM	TCGA	PYTPFDT	DEG_SCF_FBW7_1	0.1389
p.D427N	DO24457	LUAD	ICGC	PYTPFDT	DEG_SCF_FBW7_1	0.1389
p.D427N	DO37436	SKCM	ICGC	PYTPFDT	DEG_SCF_FBW7_1	0.1389
p.D431N	TCGA-33-A4WN	LUSC	TCGA	PYTPFDT	DEG_SCF_FBW7_1	0.25
p.D431N	TCGA-FW-A3R5	SKCM	TCGA	PYTPFDT	DEG_SCF_FBW7_1	0.25
p.D431N	DO219121	LUSC	ICGC	PYTPFDT	DEG_SCF_FBW7_1	0.25
p.D431N	DO37406	SKCM	ICGC	PYTPFDT	DEG_SCF_FBW7_1	0.25
p.D427H	TCGA-85-8070	LUSC	TCGA	PYTPFDT	DEG_SCF_FBW7_1	0.1389
p.D427H	DO26581	LUSC	ICGC	PYTPFDT	DEG_SCF_FBW7_1	0.1389
p.D431G	TCGA-85-8288	LUSC	TCGA	PYTPFDT	DEG_SCF_FBW7_1	0.25
p.D431G	DO26963	LUSC	ICGC	PYTPFDT	DEG_SCF_FBW7_1	0.25
p.S442L	TCGA-B5-A11Y	UCEC	TCGA	PYTPFDT	DEG_SCF_FBW7_1	0.2778
p.S442L	TCGA-T1-A6J8	LIHC	TCGA	PYTPFDT	DEG_SCF_FBW7_1	0.2778
p.S442L	DO219582	LIHC	ICGC	PYTPFDT	DEG_SCF_FBW7_1	0.2778
p.S442L	DO40889	UCEC	ICGC	PYTPFDT	DEG_SCF_FBW7_1	0.2778
p.S442L	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	PYTPFDT	DEG_SCF_FBW7_1	0.2778
p.S442L	KARPAS-1106P	haematopoietic_and_lymphoid_tissue	COSMIC	PYTPFDT	DEG_SCF_FBW7_1	0.2778
p.P437Q	TCGA-D3-A2JP	SKCM	TCGA	PYTPFDT	DEG_SCF_FBW7_1	0.7035
p.P437Q	DO47407	SKCM	ICGC	PYTPFDT	DEG_SCF_FBW7_1	0.7035
p.D429N	TCGA-FW-A3R5	SKCM	TCGA	PYTPFDT	DEG_SCF_FBW7_1	0.1944
p.D429N	DO37406	SKCM	ICGC	PYTPFDT	DEG_SCF_FBW7_1	0.1944
p.P434L	TCGA-GL-6846	KIRP	TCGA	PYTPFDT	DEG_SCF_FBW7_1	0.6471
p.P434L	DO20808	KIRP	ICGC	PYTPFDT	DEG_SCF_FBW7_1	0.6471
p.E424K	TCGA-GN-A269	SKCM	TCGA	PYTPFDT	DEG_SCF_FBW7_1	0.0556
p.E424K	DO37483	SKCM	ICGC	PYTPFDT	DEG_SCF_FBW7_1	0.0556
p.E432Q	TCGA-ZF-AA51	BLCA	TCGA	PYTPFDT	DEG_SCF_FBW7_1	0.2778
p.E432Q	DO219093	BLCA	ICGC	PYTPFDT	DEG_SCF_FBW7_1	0.2778
p.P441L	DO229502	SKCA	ICGC	PYTPFDT	DEG_SCF_FBW7_1	0.3056
p.D430N	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	PYTPFDT	DEG_SCF_FBW7_1	0.2222
p.D430N	ACH-000825	Lung Cancer	CCLE	PYTPFDT	DEG_SCF_FBW7_1	0.2222
p.D430N	HOP-92	lung	COSMIC	PYTPFDT	DEG_SCF_FBW7_1	0.2222
p.T436A	SIDM00214	Colorectal Carcinoma	GDSC	PYTPFDT	DEG_SCF_FBW7_1	0.7139
p.T436A	ACH-000955	Colon/Colorectal Cancer	CCLE	PYTPFDT	DEG_SCF_FBW7_1	0.7139
p.T436A	SNU-407	large_intestine	COSMIC	PYTPFDT	DEG_SCF_FBW7_1	0.7139
p.E428K	SIDM01582	Gastric Carcinoma	GDSC	PYTPFDT	DEG_SCF_FBW7_1	0.1667
p.E428K	ACH-000507	Gastric Cancer	CCLE	PYTPFDT	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PYTPFDT

Degron related mutations and impact score

Drug responses associated with SLC24A3 mutations

All proteins holding degron of PYTPFDT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC58	Sodium/potassium/calcium exchanger 3	DEG_SCF_FBW7_1	434:440	PYTPFDT	FBXW7	0.9904	More...