DegronMD - Q9HCN4(GPN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E286K	TCGA-DK-A3X1	BLCA	TCGA	QREQLERLR	DEG_APCC_DBOX_1	288:296	Mutation rewiring degron network	0.2778
p.R289C	TCGA-EO-A22U	UCEC	TCGA	QREQLERLR	DEG_APCC_DBOX_1	288:296	Mutation altering degron motif	0.8301
p.L280P	DO230346	COCA	ICGC	QREQLERLR	DEG_APCC_DBOX_1	288:296	Mutation rewiring degron network	0.1111
p.Q288H	DO228552	LICA	ICGC	QREQLERLR	DEG_APCC_DBOX_1	288:296	Mutation altering degron motif	0.647
p.R294L	DO229041	LICA	ICGC	QREQLERLR	DEG_APCC_DBOX_1	288:296	Mutation altering degron motif	0.7316
p.A283T	DO232224	PBCA	ICGC	QREQLERLR	DEG_APCC_DBOX_1	288:296	Mutation rewiring degron network	0.1944
p.R294H	DO50078	UCEC	ICGC	QREQLERLR	DEG_APCC_DBOX_1	288:296	Mutation altering degron motif	0.7133
p.R294H	ACH-001610	Brain Cancer	CCLE	QREQLERLR	DEG_APCC_DBOX_1	288:296	Mutation altering degron motif	0.7133
p.R296Q	ACH-000785	Lung Cancer	CCLE	QREQLERLR	DEG_APCC_DBOX_1	288:296	Mutation altering degron motif	0.6218
p.R296Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	QREQLERLR	DEG_APCC_DBOX_1	288:296	Mutation altering degron motif	0.6218
p.R296Q	ACH-002371	Non-Cancerous	CCLE	QREQLERLR	DEG_APCC_DBOX_1	288:296	Mutation altering degron motif	0.6218
p.E293G	ACH-000952	Prostate Cancer	CCLE	QREQLERLR	DEG_APCC_DBOX_1	288:296	Mutation altering degron motif	0.6087
p.L295I	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	QREQLERLR	DEG_APCC_DBOX_1	288:296	Mutation altering degron motif	0.6063
p.L283I	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	QREQLERLR	DEG_APCC_DBOX_1	288:296	Mutation rewiring degron network	0.1944
p.M299R	NCI-N87	stomach	COSMIC	QREQLERLR	DEG_APCC_DBOX_1	288:296	Mutation rewiring degron network	0.25
p.M287R	NCI-N87	stomach	COSMIC	QREQLERLR	DEG_APCC_DBOX_1	288:296	Mutation rewiring degron network	0.3056
p.S285L	KARPAS-299	haematopoietic and lymphoid tissue	COSMIC	QREQLERLR	DEG_APCC_DBOX_1	288:296	Mutation rewiring degron network	0.25

Kaplan plot for GPN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPN1

UniProt ID: Q9HCN4

Entrez ID: 11321

Protein name: GPN-loop GTPase 1 (EC 3.6.5.-) (MBD2-interacting protein) (MBDin) (RNAPII-associated protein 4) (XPA-binding protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GPN1 in